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Titolo:
CARDIOGENIC-SHOCK INDUCED BY COCAINE IN SWINE WITH NORMAL CORONARY-ARTERIES
Autore:
NUNEZ BD; MIAO L; KUNTZ RE; ROSS JN; GLADSTONE S; BAIM DS; GORDON PC; MORGAN JP; CARROZZA JP;
Indirizzi:
BETH ISRAEL HOSP,DIV CARDIOVASC,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DIV CARDIOVASC,330 BROOKLINE AVE BOSTON MA 02215 TUFTS UNIV,SCH VET MED N GRAFTON MA 00000
Titolo Testata:
Cardiovascular Research
fascicolo: 1, volume: 28, anno: 1994,
pagine: 105 - 111
SICI:
0008-6363(1994)28:1<105:CIBCIS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC HEMODYNAMICS; CONSCIOUS DOGS; BLOOD-FLOW; INTOXICATION; ABUSE; HEART; VASOCONSTRICTION; DEPRESSION; LETHALITY; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Nunez et al., "CARDIOGENIC-SHOCK INDUCED BY COCAINE IN SWINE WITH NORMAL CORONARY-ARTERIES", Cardiovascular Research, 28(1), 1994, pp. 105-111

Abstract

Objective: The aim was to test the hypothesis that acute intravenous cocaine administration can cause coronary microvascular constriction culminating in myocardial ischaemia and cardiogenic shock. Methods: Systemic haemodynamic variables and coronary blood flow were measured in 14 Yorkshire swine at baseline and following intravenous administration of 1, 3, and 10 mg.kg-1 of cocaine. Epicardial coronary artery diameter was measured from coronary arteriograms and coronary flow velocitywas recorded with a Doppler flow wire. Results: Cocaine produced a decrease in mean arterial pressure (65%), cardiac output (80%), and stroke volume (80%), and an increase in pulmonary artery diastolic pressure (60%). Although coronary blood flow decreased by 70%, epicardial coronary cross sectional area decreased by only 37-45%. Pretreatment withprazosin did not abolish the decrease in coronary blood flow. After administration of 10 mg.kg-1 of cocaine, five of 14 animals developed myocardial ischaemia and cardiogenic shock, culminating in ventricular fibrillation and death. Conclusions: In anaesthetised Yorkshire swine,cumulative intravenous doses of cocaine caused a significant reduction in coronary blood flow resulting in myocardial ischaemia, which cannot be attributed to epicardial vasoconstriction alone. This suggests that cocaine-induced coronary ischaemia may result from microvascular constriction, which is only partially prevented by alpha1 blockade. In addition, direct toxic effects of cocaine on the myocardium may also contribute to the development of cardiogenic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:56:49