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Titolo:
OPIOID RECEPTOR DENSITY CHANGES IN ALZHEIMER AMYGDALA AND PUTAMEN
Autore:
BARG J; BELCHEVA M; ROWINSKI J; HO A; BURKE WJ; CHUNG HD; SCHMIDT CA; COSCIA CJ;
Indirizzi:
ST LOUIS UNIV,DEPT BIOCHEM & MOLEC BIOL,1402 S GRAND BLVD ST LOUIS MO63104 ST LOUIS UNIV,DEPT BIOCHEM & MOLEC BIOL ST LOUIS MO 63104 ST LOUIS UNIV,DEPT PATHOL ST LOUIS MO 63104 ST LOUIS UNIV,DEPT NEUROL ST LOUIS MO 63104 WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 632, anno: 1993,
pagine: 209 - 215
SICI:
0006-8993(1993)632:1-2<209:ORDCIA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PROTEIN; BINDING-SITES; SENILE DEMENTIA; HUMAN-BRAIN; CYCLASE ACTIVITY; HUMAN FOREBRAIN; MESSENGER-RNA; RAT-BRAIN; DISEASE; NEURONS;
Keywords:
OPIOID RECEPTOR; ALZHEIMERS DISEASE; AMYGDALA; FRONTAL CORTEX; AUTORADIOGRAPHY; GTP ANALOG; AUTORADIOGRAPHY; HUMAN BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J. Barg et al., "OPIOID RECEPTOR DENSITY CHANGES IN ALZHEIMER AMYGDALA AND PUTAMEN", Brain research, 632(1-2), 1993, pp. 209-215

Abstract

Since opioids can influence the release of acetylcholine, substance Pand a number of other neurotransmitters that have been implicated in the pathogenesis of Alzheimer's disease (AD), it is of interest to assess opioid receptor levels in AD. We have examined mu, delta and kappaopioid receptor binding parameters, binding sensitivity to a GTP analog and distribution in amygdala, frontal cortex and putamen of AD brain. Control brains were matched according to age, sex, post-mortem interval and storage time. K-d values and GTP analog binding sensitivity did not differ in AD and control brains. B-max values for mu ([H-3]DAMGE) sites also appeared unaffected by in vitro binding assays. In contrast, kappa ([H-3]U69593) and delta ([H-3]DSLET) opioid receptor levels, were significantly changed. In AD amygdala kappa B-max values increased from control levels of 123 +/- 12 to 168 +/- 13 fmol/mg protein, whereas densities of kappa and delta sites were decreased from 94 +/- 8to 48 +/- 8 and 102 +/- 3.6 to 69 +/- 8.5 fmol/mg protein, respectively, in putamen. Autoradiography revealed corresponding differences in the distribution of kappa opioid receptors. The findings indicate thatthe kappa binding site, which is quantitatively the major opioid receptor class in human brain, undergoes marked changes in AD amygdala andputamen.

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Documento generato il 25/01/20 alle ore 19:02:06