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Titolo:
SEGMENTAL PATTERNING OF RAT AND CHICKEN SYMPATHETIC PREGANGLIONIC NEURONS - CORRELATION BETWEEN SOMA POSITION AND AXON PROJECTION PATHWAY
Autore:
FOREHAND CJ; EZERMAN EB; RUBIN E; GLOVER JC;
Indirizzi:
UNIV VERMONT,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT BIOL PSYCHIAT NEW YORK NY 10032 UNIV OSLO,INST BASIC MED SCI,DEPT PHYSIOL N-0317 OSLO NORWAY
Titolo Testata:
The Journal of neuroscience
fascicolo: 1, volume: 14, anno: 1994,
pagine: 231 - 241
SICI:
0270-6474(1994)14:1<231:SPORAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR CERVICAL-GANGLION; EMBRYO SPINAL-CORD; NERVOUS-SYSTEM; LINEAGE RESTRICTIONS; ZEBRAFISH EMBRYOS; MAMMALIAN MUSCLE; RE-INNERVATION; MOTOR NUCLEUS; CELL LINEAGE; HINDBRAIN;
Keywords:
ROSTROCAUDAL GRADIENT; SPINAL CORD; NEUROMERE; AUTONOMIC NERVOUS SYSTEM; DEXTRAN AMINES; EMBRYOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Forehand et al., "SEGMENTAL PATTERNING OF RAT AND CHICKEN SYMPATHETIC PREGANGLIONIC NEURONS - CORRELATION BETWEEN SOMA POSITION AND AXON PROJECTION PATHWAY", The Journal of neuroscience, 14(1), 1994, pp. 231-241

Abstract

The segmental organization of midthoracic rat and chicken sympatheticpreganglionic neurons was examined by retrograde labeling in vivo andinvitro. The results demonstrate that individual sympathetic preganglionic neurons project only rostrally or caudally within the sympathetic chain, even though the spinal segment in which they reside provides innervation to both rostral and caudal ganglia. In addition, there is both a segmental and an intrasegmental pattern in the thoracic sympathetic column, in which the position of preganglionic neurons is relatedto the direction they project in the sympathetic chain. Thoracic sympathetic preganglionic neurons are organized into discrete segmental units, each of which exhibits an internal rostrocaudal polarity with respect to the direction of axon projection in the sympathetic chain. Therostrocaudal bias of this internal polarity is graded from segment tosegment along the longitudinal axis. Since there is minimal overlap between thoracic segments, the transition from one segment to another entails a sharp change in the pathway choice of the preganglionic neurons. The organization of the preganglionic projections thus includes (1) segmental periodicity, (2) intrasegmental gradients of neuronal identity, and (3) an axial gradient of segment identity. The significance of these findings is twofold. First, they suggest a functional organization that may be related to the specificity of sympathetic reflex. Second, they reveal a cellular organization that suggests an underlying segmental pattern in the developing spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:07:57