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Titolo:
CDNA CLONING OF RAT PROTEASOME SUBUNIT RC10-II, ASSUMED TO BE RESPONSIBLE FOR TRYPSIN-LIKE CATALYTIC ACTIVITY
Autore:
NISHIMURA C; TAMURA T; AKIOKA H; TOKUNAGA F; TANAKA K; ICHIHARA A;
Indirizzi:
UNIV TOKUSHIMA,INST ENZYME RES TOKUSHIMA 770 JAPAN UNIV TOKUSHIMA,INST ENZYME RES TOKUSHIMA 770 JAPAN NIPPON KAYAKU CO LTD,APPL TOXICOL LAB TAKASAKI GUNMA 37012 JAPAN HIMEJI INST TECHNOL,FAC SCI HARIMA HYOGO 67812 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 336, anno: 1993,
pagine: 462 - 466
SICI:
0014-5793(1993)336:3<462:CCORPS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; HEPATOMA-CELLS; MULTICATALYTIC PROTEINASE; LIVER; SITE; C5;
Keywords:
CDNA CLONING; MULTICATALYTIC PROTEINASE; PROTEASOME; SUBUNIT RC10-II; TRYPSIN-LIKE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C. Nishimura et al., "CDNA CLONING OF RAT PROTEASOME SUBUNIT RC10-II, ASSUMED TO BE RESPONSIBLE FOR TRYPSIN-LIKE CATALYTIC ACTIVITY", FEBS letters, 336(3), 1993, pp. 462-466

Abstract

The nucleotide sequence of a cDNA that encodes a new subunit, named RC10-II, of the 20S proteasome of rat embryonic brain has been determined. The polypeptide predicted from the open reading frame consists of 205 amino acid residues with a calculated molecular weight of 22,965 and isoelectric point of 6.15. Computer analysis showed that RC10-II belongs to the B-type subgroup of proteasomes, differing clearly from alpha-type subunits of the proteasome gene family. The primary structureof RC10-II was found to contain the partial amino acid sequences of several fragments of subunit 13, which has a cysteinyl residue criticalfor the trypsin-like catalytic activity, as reported by L.R. Dick et al. [Biochemistry 31, 7347-7355, 1992], suggesting that RC10-II is a proteasomal subunit necessary for the expression of tryptic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:44:36