Catalogo Articoli (Spogli Riviste)
Titolo: QT(C)-MEASUREMENTS - A CASE-CONTROL STUDY ON SERUM ELECTROLYTES .2.
Autore: VERVAET P; AMERY W;
- JANSSEN RES FDN,DEPT INT PHARMACOVIGILANCE,PHARMACOEPIDEMIOL SECT BEERSE BELGIUM
- Titolo Testata:
- Acta cardiologica
pagine: 565 - 578
- CASE-CONTROL STUDY; QT(C)-INTERVAL PROLONGATION; HYPOKALEMIA; VENTRICULAR ARRHYTHMIAS;
- Tipo documento:
- Settore Disciplinare:
- Science Citation Index Expanded
- Indirizzi per estratti:
- P. Vervaet e W. Amery, "QT(C)-MEASUREMENTS - A CASE-CONTROL STUDY ON SERUM ELECTROLYTES .2.", Acta cardiologica, 48(6), 1993, pp. 565-578
Abstract This is a report on a prospective case-control study, in which a group of patients with an electrocardiographic diagnosis of QT(c)-prolongation (cases) was compared with a group of patients with a normal QT(c)(controls) for the presence of potential causative factors. Twelve cases and twelve carefully-matched controls were entered during a 1-yearrecruitment period. Ventricular arrhythmias were more frequent amongst the cases than amongst the controls (7/12 the cases, only 2/12 controls). Blood was sampled around the time of the ECG-recording in all patients. Forearm exercise (pumping) to increase venous blood pooling was prohibited before this blood sampling. The serum cation levels (potassium, calcium, magnesium) were determined in one central laboratory. Serum potassium levels were inversely correlated with the QT(c)-interval. Such a correlation was not found for the other two cations, although calcium levels also tended to be lower in patients with a long QT(c). The findings, in addition, suggest that serum potassium values in the lower normal range (i.e. < 4 meq/l) might predispose to the development of ventricular arrhythmias. In view of these results, the diagnostic work-up of a patient with a long QT(c) is incomplete without a serum -K+, and possibly serum -Ca2+, assessment.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:07:11