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Titolo:
POSTNATAL-DEVELOPMENT OF FUNCTIONAL DOPAMINE, OPIOID AND TACHYKININ RECEPTORS THAT REGULATE ACETYLCHOLINE-RELEASE FROM RAT NEOSTRIATAL SLICES - EFFECT OF 6-HYDROXYDOPAMINE LESION
Autore:
PEREZNAVARRO E; ALBERCH J; MARSAL J;
Indirizzi:
UNIV BARCELONA,FAC MED,DEPT BIOL CELLULAR & ANAT PATOL,CASANOVA 143 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP BELLVITGE,FAC MED,DEPT BIOL CELLULAR & ANAT PATOLE-08036 BARCELONA SPAIN
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 6, volume: 11, anno: 1993,
pagine: 701 - 708
SICI:
0736-5748(1993)11:6<701:POFDOA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLATE-CYCLASE ACTIVITY; ENDOGENOUS ACETYLCHOLINE; CHOLINERGIC NEURONS; STRIATAL SLICES; MESSENGER-RNA; NEUROTRANSMITTER RELEASE; DIFFERENTIAL ONTOGENY; SUBSTANCE-P; DELTA; INHIBITION;
Keywords:
STRIATUM; RELEASE OF ENDOGENOUS ACETYLCHOLINE; POSTNATAL DEVELOPMENT; DOPAMINE; TACHYKININS; OPIOIDS; 6-HYDROXYDOPAMINE LESION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E. Pereznavarro et al., "POSTNATAL-DEVELOPMENT OF FUNCTIONAL DOPAMINE, OPIOID AND TACHYKININ RECEPTORS THAT REGULATE ACETYLCHOLINE-RELEASE FROM RAT NEOSTRIATAL SLICES - EFFECT OF 6-HYDROXYDOPAMINE LESION", International journal of developmental neuroscience, 11(6), 1993, pp. 701-708

Abstract

In the present work we have studied the postnatal development of functional dopamine, opioid and tachykinin receptors, which regulate cholinergic activity in the neostriatum. The release of endogenous acetylcholine from rat striatal slices was measured using a chemiluminescent method. We have observed that the inhibition mediated by dopamine through D2 receptors was not detectable until postnatal day 10, whereas theinhibition mediated by opioid receptors was detectable at postnatal day 15 for delta-receptors ([D-Pen2, D-Pen5]-enkephalin) and at postnatal day 21 for mu-receptors ([D-Ala2, Gly(ol)5]-enkephalin). Excitatoryeffect mediated by tachykinins through NK1 ([Sar9, Met(02)11]-Substance P), NK2 ([Nle10]-Neurokinin A4-10), or NK3 (senktide) receptors wasalready detectable at postnatal day 5. In order to examine the influence of dopamine in the development of tachykinin and opioid systems inthe neostriatum, we induced dopamine deficiency by intraventricular injection of 6-hydroxydopamine at postnatal day 3. We observed an increase in senktide-evoked acetylcholine release at postnatal day 30. The effect produced by [Sar9, Met(02)11]-Substance P and [Nle10]-Neurokinin A4-10 was not modified. Furthermore, at postnatal day 35, we could observed that the two opioid receptor agonists have no effect. Our results show that dopamine, tachykinins and opioids are already able to mediate the modulation of acetylcholine release in early stages of development with a different pattern of postnatal development. Furthermore,the integrity of a dopaminergic system plays an important role in thefunctional development of the neostriatal cholinergic neurons which are differentially modulated by opioids or tachykinins.

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Documento generato il 29/03/20 alle ore 08:35:46