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Titolo:
AN ANIMAL-MODEL OF TINNITUS - A DECADE OF DEVELOPMENT
Autore:
JASTREBOFF PJ; SASAKI CT;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT SURG,DIV OTOLARYNGOL,10 S PINE ST,MSTF BLDG,RM 434F BALTIMORE MD 21201 YALE UNIV,SCH MED,DEPT SURG,OTOLARYNGOL SECT NEW HAVEN CT 06510
Titolo Testata:
The American journal of otology
fascicolo: 1, volume: 15, anno: 1994,
pagine: 19 - 27
SICI:
0192-9763(1994)15:1<19:AAOT-A>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; OUTER HAIR-CELLS; PHANTOM AUDITORY-PERCEPTION; CONDITIONED SUPPRESSION; FETAL TOXICITY; SALICYLATE; QUININE; RATS; ELECTROMOTILITY; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Jastreboff e C.T. Sasaki, "AN ANIMAL-MODEL OF TINNITUS - A DECADE OF DEVELOPMENT", The American journal of otology, 15(1), 1994, pp. 19-27

Abstract

Although tinnitus affects approximately 9 million people in the United States, a cure remains elusive and the mechanisms of its origin are speculative. The crucial obstacle in tinnitus research has been the lack of an animal model. Over the last decade we have been creating sucha model by combining a variety of methodologies, including a behavioral component, to allow for the detection of tinnitus perception. Initially, 2-deoxyglucose had been used to map changes in the metabolic activity after unilateral destruction of the cochlea. It has been found that the initial decrease of the metabolic rate in the auditory nuclei recovered to preoperative values, which could be attributable to the development of tinnitus. The spontaneous activity oi single units recorded from the inferior colliculus before and after salicylate administration revealed an increase of discharges, which might reflect the presence of salicylate-induced tinnitus. Recent data have confirmed, and further elaborated this observation, including the discovery of abnormal, epileptic-like, neuronal activity. Finally, the authors have developed a behavioral model of tinnitus, tested it extensively, and used itto measure tinnitus pitch and loudness. The model is presently used for investigating the hypotheses for the mechanisms of tinnitus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:33:18