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Titolo:
BRANCHED-CHAIN AMINO-ACIDS AND AMYOTROPHIC-LATERAL-SCLEROSIS - A TREATMENT FAILURE
Autore:
BEGHI E; FIORDELLI E; MORA G; MAZZINI L; POLONI M; PINELLI P; TESTA D; CORNELIO F; LEONE M; BOTTACCHI E; CHIO A; SCHIFFER D; MAGI S; SABATELLI M; TONALI P; FORMICA A; BERARDELLI A; MANFREDI M; CATTICH N; FERRANNINI E; LIVREA P; CORETTI A; HUBER R; MUSICCO M;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62 I-20157 MILAN ITALY OSPED SAN GERARDO MONZA ITALY FDN CLIN LAVORO,CTR MED RIABILITAZ VERUNO ITALY UNIV MILAN,NEUROL CLIN 1 I-20122 MILAN ITALY IST NAZL NEUROL C BESTA MILAN ITALY OSPED REG AOSTA ITALY UNIV TURIN,NEUROL CLIN 2 I-10124 TURIN ITALY CATHOLIC UNIV SACRED HEART,NEUROL CLIN I-00168 ROME ITALY UNIV ROMA LA SAPIENZA,NEUROL CLIN 5 I-00185 ROME ITALY OSPED POLICLIN,NEUROL CLIN BARI ITALY OSPED BOLZANO,DIV NEUROL BOLZANO ITALY CNR,IST TECHNOL BIOMED AVANZATE I-20133 MILAN ITALY
Titolo Testata:
Neurology
fascicolo: 12, volume: 43, anno: 1993,
pagine: 2466 - 2470
SICI:
0028-3878(1993)43:12<2466:BAAA-A>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR NEURON DISEASE; GLUTAMATE; MORTALITY; METABOLISM; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
E. Beghi et al., "BRANCHED-CHAIN AMINO-ACIDS AND AMYOTROPHIC-LATERAL-SCLEROSIS - A TREATMENT FAILURE", Neurology, 43(12), 1993, pp. 2466-2470

Abstract

We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g,L-isoleucine 6 g and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 placebo) when a total of 126 ALS patients had been recruited. This finding, associated with the lack ofefficacy of BCAA (measured by comparing the disability scales in the two treatment groups), led the Data Monitoring Committee to require cessation of the trial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:38:09