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Titolo:
THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD).4. RATES OF COGNITIVE CHANGE IN THE LONGITUDINAL ASSESSMENT OF PROBABLE ALZHEIMERS-DISEASE
Autore:
MORRIS JC; EDLAND S; CLARK C; GALASKO D; KOSS E; MOHS R; VANBELLE G; FILLENBAUM G; HEYMAN A;
Indirizzi:
WASHINGTON UNIV,SCH MED,MEMORY & AGING PROJECT,660 S EUCLID,BOX 8111 ST LOUIS MO 63110 UNIV PENN PHILADELPHIA PA 19104 UNIV CALIF SAN DIEGO LA JOLLA CA 92093 CASE WESTERN RESERVE UNIV CLEVELAND OH 44106 DUKE UNIV,MED CTR DURHAM NC 27710 MT SINAI BRONX VET ADM MED CTR NEW YORK NY 00000
Titolo Testata:
Neurology
fascicolo: 12, volume: 43, anno: 1993,
pagine: 2457 - 2465
SICI:
0028-3878(1993)43:12<2457:TCTEAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILD SENILE DEMENTIA; PROGRESSION; PREDICTORS; IMPAIRMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Morris et al., "THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD).4. RATES OF COGNITIVE CHANGE IN THE LONGITUDINAL ASSESSMENT OF PROBABLE ALZHEIMERS-DISEASE", Neurology, 43(12), 1993, pp. 2457-2465

Abstract

Reliable information on rate of progression of cognitive impairment in probable Alzheimer's disease (AD) is important for evaluating possible beneficial effects of therapeutic agents and in planning long-term care for patients with this chronic illness. However, wide variabilityexists in published rates of change for psychometric measures of the dementing process, and there is need for an accurate analysis of largenumbers of persons with the disorder studied over long periods. Utilizing the large, well-characterized sample of the Consortium to Establish a Registry for Alzheimer's Disease and employing a least squares regression method to adjust for different levels of impairment and periods of observation, we report rates of change on the Short Blessed Test, Mini-Mental State Examination, Blessed Dementia Scale, Clinical Dementia Rating, and other cognitive measures in 430 patients with probable AD (mean age at entry = 70.9 +/- 8.0 SD years) studied for up to 4 years. We found that rate-of-change determinations are less reliable when the observation period is 1 year or less, that dementia progressionmay be nonlinear when described by certain measures, and that simple change scores do not accurately characterize the rate of decline. We also found that rate of progression in AD is determined by the severityof cognitive impairment: the less severe the dementia, the slower therate of decline.

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Documento generato il 23/09/20 alle ore 08:39:03