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Titolo:
EFFECTS OF BERAPROST SODIUM, A STABLE ANALOG OF PROSTACYCLIN, ON HYPERPLASIA, HYPERTROPHY AND GLYCOSAMINOGLYCAN SYNTHESIS OF RAT AORTIC SMOOTH-MUSCLE CELLS
Autore:
KOH E; MORIMOTO S; JIANG BB; INOUE T; NABATA T; KITANO S; YASUDA O; FUKUO K; OGIHARA T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT GERIATR MED,2-2 YAMADAOKA SUITA OSAKA 553 JAPAN OSAKA UNIV,SCH MED,DEPT GERIATR MED SUITA OSAKA 553 JAPAN
Titolo Testata:
Artery
fascicolo: 5, volume: 20, anno: 1993,
pagine: 242 - 252
SICI:
0098-6127(1993)20:5<242:EOBSAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSIVE RAT; DNA-SYNTHESIS; RABBIT; TRK-100; PROSTAGLANDIN-I2; HYPERPLOIDY; COMPLEXES; INVITRO;
Keywords:
BERAPROST SODIUM; HYPERPLASIA; HYPERTROPHY; GLYCOSAMINOGLYCAN; VASCULAR SMOOTH MUSCLE CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
E. Koh et al., "EFFECTS OF BERAPROST SODIUM, A STABLE ANALOG OF PROSTACYCLIN, ON HYPERPLASIA, HYPERTROPHY AND GLYCOSAMINOGLYCAN SYNTHESIS OF RAT AORTIC SMOOTH-MUSCLE CELLS", Artery, 20(5), 1993, pp. 242-252

Abstract

The effects of beraprost sodium, a stable analogue of prostacyclin, on the syntheses of DNA, protein and glycosaminoglycans (GAG) of cultured vascular smooth muscle cells (SMC) were studied. SMC were isolated from the thoracic aorta of male Wistar rats. The syntheses of DNA, protein and GAG of SMC were determined by incorporations of [H-3]thymidine, [H-3]leucine and [S-35]sulfuric acid, respectively. Insulin at a concentration of 10(-6) M stimulated DNA synthesis 4 fold compared to control. Beraprost sodium suppressed the insulin-stimulated DNA synthesis dose-dependently at concentrations greater than 10(-7) M and suppressed it by 68% at 10(-5) M. Platelet derived growth factor (PDGF) at a concentration of 20 ng/ml stimulated DNA synthesis 6 fold compared to control. Beraprost sodium suppressed the PDGF-stimulated DNA synthesisdose-dependently at concentrations greater than 10(-7) M and suppressed it by 51% at 10(-5) M. Beraprost sodium suppressed GAG synthesis dose-dependently at concentrations greater than 10(-7) M and suppressed it by 49% at 10(-5) M. However, beraprost sodium at concentrations up to 10(-5) M did not affect protein synthesis. These results indicate that beraprost sodium suppressed the proliferation and GAG synthesis ofSMC but did not affect hypertrophy. Beraprost sodium may be a potent antiarteriosclerotic agent through suppression of hyperplasia of SMC and modification of matrix protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:55:25