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Titolo:
PORTAL-HYPERTENSION - ITS EFFECTS ON GASTRIC FUNCTION AND ETHANOL-INDUCED GASTRIC-MUCOSAL DAMAGE IN RATS
Autore:
MA JJ; CHO CH; OGLE CW;
Indirizzi:
UNIV HONG KONG,FAC MED,DEPT PHARMACOL,5 SASSOON RD HONG KONG HONG KONG UNIV HONG KONG,FAC MED,DEPT PHARMACOL HONG KONG HONG KONG
Titolo Testata:
Digestive diseases and sciences
fascicolo: 12, volume: 38, anno: 1993,
pagine: 2203 - 2208
SICI:
0163-2116(1993)38:12<2203:P-IEOG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICALS; GASTROPATHY; ULCERATION; LESIONS; VAGUS; ACID;
Keywords:
PORTAL HYPERTENSION; GASTRIC FUNCTION; ETHANOL; GASTRIC DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Ma et al., "PORTAL-HYPERTENSION - ITS EFFECTS ON GASTRIC FUNCTION AND ETHANOL-INDUCED GASTRIC-MUCOSAL DAMAGE IN RATS", Digestive diseases and sciences, 38(12), 1993, pp. 2203-2208

Abstract

The time-course effects of portal hypertension on gastric secretory function, mucosal blood flow, vascular permeability, and ethanol-induced gastric mucosal damage were examined in anesthetized rats. Partial ligation of the portal vein effectively produced portal hypertension one to three days later but the raised pressure returned to normal on the sixth day after ligation. This time-course effect coincided with reduced pepsin secretion and mucosal blood flow and also with potentiatedethanol-induced mucosal damage during the first to third days. These effects started to tail off on the sixth day. However, gastric acid output was significantly reduced on the third day, and this was strongest on the sixth day after operation. Portal vein ligation also reduced basal vascular permeability, which was markedly potentiated after ethanol treatment. It is concluded that: (1) portal vein blood pressure changes are a time-dependent process following ligation; (2) changes in gastric mucosal blood flow (GMBF) and lesion formation are closely related to portal hypertension; (3) gastric mucosal injury is associated with vascular damage, as evidenced by increased in vascular permeability; and (4) pepsin but not acid secretion is closely related to the state of the GMBF.

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Documento generato il 12/08/20 alle ore 21:02:18