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Titolo:
CD72 LIGATION REGULATES DEFECTIVE NAIVE NEWBORN B-CELL RESPONSES
Autore:
HOWARD LM; REEN DJ;
Indirizzi:
OUR LADYS HOSP SICK CHILDREN,CHILDRENS RES CTR DUBLIN 12 IRELAND
Titolo Testata:
Cellular immunology
fascicolo: 2, volume: 175, anno: 1997,
pagine: 179 - 188
SICI:
0008-8749(1997)175:2<179:CLRDNN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA PRODUCTION; HUMAN CORD-BLOOD; T-CELL; LYMPHOCYTES-B; NEONATAL LYMPHOCYTES; COSTIMULATORY ACTIVITY; ACTIVATION ANTIGEN-B7; PERIPHERAL-BLOOD; SURFACE PROTEIN; CD40 ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Howard e D.J. Reen, "CD72 LIGATION REGULATES DEFECTIVE NAIVE NEWBORN B-CELL RESPONSES", Cellular immunology, 175(2), 1997, pp. 179-188

Abstract

The biological basis for reduced Ig production by naive newborn B cells compared to adult peripheral blood B cells is not fully understood. In a Con A + IL-2 T cell-dependent system using ''competent'' adult Tcells, adult B cells produced large amounts of IgM, IgG, and IgA, while cord B cells were restricted to low levels of only IgM production. Cord B cell activation was also diminished. The contribution of specific B-T cell contact-mediated events to the diminished cord B cell response in this system, using mAbs to CD40, CD28, CD80, and CD72, were investigated, as well as regulation of B cell Ig production by cytokines. alpha CD72 ligation increased cord B cell activation and IgM production, but did not affect adult B cells. Blocking alpha CD40 mAb inhibited cord B cell Ig production completely, but only partly inhibited adult B cell Ig production even at high concentration, suggesting a greater sensitivity of cord B cells to disruption of the CD40-CD40L interaction. Addition of IL-10 did not increase cord B cell Ig production, while adult B cell Ig production was increased. However, combined addition of IL-10 and alpha CD72 significantly increased cord B cell Ig production over that in the presence of either alpha CD72 or IL-10 alone, but had no effect on adult B cells over that of IL-10 alone. These data suggest that the diminished T cell-dependent response of cord B cells is due to reduced or absent CD72 ligation. CD72 ligation plays an important role in the induction of primary responses by naive B cells. CD72 modulation of naive B cell sensitivity to IL-10 stimulation may have implications in the induction of class switch, which is deficient in newborn B cells. Since all T cells express CD5 constitutively, thesedata also suggest the existence of another ligand for CD72. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 13:18:34