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Titolo:
ENDOTHELIN ET(A) AND ET(B) RECEPTORS MEDIATE VASOCONSTRICTION AND PROSTANOID RELEASE IN THE ISOLATED KIDNEY OF THE RAT
Autore:
WARNER TD; BATTISTINI B; ALLCOCK GH; VANE JR;
Indirizzi:
ST BARTHOLOMEWS HOSP,COLL MED,WILLIAM HARVEY RES INST,CHARTERHOUSE SQLONDON EC1M 6BQ ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 250, anno: 1993,
pagine: 447 - 453
SICI:
0014-2999(1993)250:3<447:EEAERM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY INTERSTITIAL-CELLS; TISSUE-CULTURE; IDENTIFICATION; STIMULATION; VASOPRESSIN; EXPRESSION; SUBTYPES; BINDING; CLONING; INVIVO;
Keywords:
ENDOTHELIN; SARAFOTOXIN; PROSTANOID; ENDOTHELIN RECEPTOR; PD 145065; KIDNEY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Warner et al., "ENDOTHELIN ET(A) AND ET(B) RECEPTORS MEDIATE VASOCONSTRICTION AND PROSTANOID RELEASE IN THE ISOLATED KIDNEY OF THE RAT", European journal of pharmacology, 250(3), 1993, pp. 447-453

Abstract

Endothelin-1 or sarafotoxin 6c (10(-12) to 10(-9) M) induced concentration-dependent increases in perfusion pressure in the isolated perfused kidney of the rat, and increased the release of 6-keto-prostaglandin F-1 alpha, prostaglandin E(2) and prostaglandin F-2 alpha. The presser effects of endothelin-1 were partially antagonised by BQ-123 (10(-6) M) and more strongly so by the endothelin ET(A/B) receptor non-selective antagonist PD 145065 (10(-6) M). PD 145065, but not BQ-123, also completely blocked the presser effects of sarafotoxin 6c. The releasesof prostanoids induced by endothelin-1 were greatly reduced by infusion of either BQ-123 or PD 145065, whereas PD 145065, but not BQ-123, strongly antagonised the releases induced by sarafotoxin 6c. These results indicate that the vasoconstrictions and the prostanoid releases induced by the endothelin/sarafotoxin peptides are mediated by the activation of both endothelin ET(A) and endothelin ET(B) receptors in the isolated perfused kidney of the rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:25:00