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Titolo:
THE EFFECTS OF 3-HYDROXYBUTYRATE AND GLUCOSE ON HUMAN T-CELL RESPONSES TO CANDIDA-ALBICANS
Autore:
GREGORY R; MCELVEEN J; TATTERSALL RB; TODD I;
Indirizzi:
UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT IMMUNOL NOTTINGHAM NG7 2UH NOTTS ENGLAND UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT IMMUNOL NOTTINGHAM NG7 2UH NOTTS ENGLAND UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT DIABET NOTTINGHAM NG7 2UH NOTTS ENGLAND
Titolo Testata:
FEMS immunology and medical microbiology
fascicolo: 4, volume: 7, anno: 1993,
pagine: 315 - 320
SICI:
0928-8244(1993)7:4<315:TEO3AG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMALITIES; LYMPHOCYTES; RAT;
Keywords:
CANDIDA ALBICANS; GLUCOSE; 3-HYDROXYBUTYRATE; T CELL; DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R. Gregory et al., "THE EFFECTS OF 3-HYDROXYBUTYRATE AND GLUCOSE ON HUMAN T-CELL RESPONSES TO CANDIDA-ALBICANS", FEMS immunology and medical microbiology, 7(4), 1993, pp. 315-320

Abstract

Diabetic patients are particularly susceptible to mucocutaneous candidosis. T lymphocytes are central to the induction of antigen-specific immune responses and may be sensitive to the biochemical abnormalitiesassociated with poorly controlled diabetes; namely, hyperglycaemia and/or ketonemia. To examine this we have studied the effect of varying concentrations of glucose and 3-hydroxybutyrate (3-HB) in cultures of human T cells stimulated with Candida albicans antigen. Proliferation of T cells from six type 1 diabetic and six non-diabetic control subjects was significantly inhibited (both P<0.05) in glucose-free medium, and at a glucose concentration of 80 mmol l(-1) as compared with cultures containing glucose at physiological concentration (5 mmol l(-1)). 16 and 32 mmol l(-1) 3-HB also inhibited T cell proliferation in the presence of 5 mmol l(-1) glucose (P<0.05). The effect of glucose and 3-HB were not additive and the inhibition was not due to cell death. 32 mmol l(-1) 3-HB had less effect when present solely during antigen pulsing than during subsequent lymphocyte stimulation, and was effective even when added after 72 h of a six day culture. This suggests that ketosis affects T cell proliferation more than antigen processing and presentation. We conclude that human antigen-specific T cell proliferation is inhibited in vitro only by concentrations of 3-HB encountered inmoderately severe diabetic ketoacidosis, and by glucose concentrations found in severe hyperosmolar non-ketotic coma. The impairment of T cell function under such extreme conditions could be implicated in the close association of diabetic ketoacidosis with deep fungal infections, particularly invasive mucormycosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:42:32