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Titolo:
RESPIRATORY ALTERATIONS WITH INTRAPERICARDIAL PROCAINE IN THE CONSCIOUS RABBIT
Autore:
BELL LB; QUANDT LM; OHAGAN KP; MITTELSTADT SW; CLIFFORD PS;
Indirizzi:
VET ADM MED CTR,RES SERV 151,5000 W NATL AVE MILWAUKEE WI 53295 MED COLL WISCONSIN,DEPT ANESTHESIOL MILWAUKEE WI 00000 MED COLL WISCONSIN,DEPT PHYSIOL MILWAUKEE WI 00000
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 12, volume: 20, anno: 1993,
pagine: 753 - 762
SICI:
0305-1870(1993)20:12<753:RAWIPI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC AFFERENTS; UNANESTHETIZED RABBITS; ARTERIAL BARORECEPTORS; REVERSIBLE BLOCKADE; LOCAL-ANESTHETICS; RELATIVE ROLES; RECEPTORS; DOGS; PERICARDIUM; HEMORRHAGE;
Keywords:
CARDIAC DENERVATION; DIAPHRAGM EMG; LOCAL ANESTHETIC; PERICARDIUM; PHRENIC NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L.B. Bell et al., "RESPIRATORY ALTERATIONS WITH INTRAPERICARDIAL PROCAINE IN THE CONSCIOUS RABBIT", Clinical and experimental pharmacology and physiology, 20(12), 1993, pp. 753-762

Abstract

1. Intrapericardial procaine, used to produce cardiac nerve blockade in both conscious and anaesthetized animals, has been reported to alsoproduce changes in respiration. This study systematically investigated the effects of two doses of intrapericardial procaine on respirationin the conscious rabbit. 2. Rabbits were pre-instrumented with a chronic diaphragm electromyogram (dEMG) recording electrode and intrapericardial catheter. Arterial pressure, heart rate, dEMG and respiratory excursions (recorded with a pneumograph) were monitored in the conscious rabbit before and after intrapericardial and intravenous infusion of2 and 5% procaine. Efficacy of cardiac nerve blockade was tested by intravenous infusion of phenyl biguanide. Arterial blood gases were determined at rest and during changes in respiration. 3. Following a low dose of intrapericardial procaine (12 mg), dEMG and respiratory excursions increased (65 +/- 13 and 76 +/- 32%, respectively) with no changein breathing frequency or arterial blood gases. Following a high doseof intrapericardial procaine (30 mg), four of six animals exhibited asimilar response. However, four of the six rabbits also exhibited a second type of response pattern characterized by a further increase in respiratory efforts (430 +/- 336%), abolition of dEMG, and a mild hypoxaemia. 4. Intravenous infusion of a low dose of procaine was without effect, whereas intravenous infusion of a high dose of procaine produced minor behavioural responses. 5. In four additional anaesthetized rabbits, it was demonstrated that high doses of intrapericardial procaine anaesthetized the phrenic nerve to produce the observed alterations in respiration. 6. We conclude that if intrapericardial procaine is used to block cardiac nerves in conscious rabbits, it should be used in a low concentration and at the lowest possible total dose to avoid complications due to changes in respiration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:20:17