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Titolo:
THE QUIPAZINE-INCREASED AND TFMPP-INCREASED CONDITIONED AVOIDANCE-RESPONSE IN RATS - ROLE OF 5-HT1C 5-HT2 RECEPTORS/
Autore:
ALHAIDER AA; AGEEL AM; GINAWI OT;
Indirizzi:
KING SAUD UNIV,COLL PHARM,DEPT PHARMACOL,POB 2457 RIYADH 11451 SAUDI ARABIA
Titolo Testata:
Neuropharmacology
fascicolo: 12, volume: 32, anno: 1993,
pagine: 1427 - 1432
SICI:
0028-3908(1993)32:12<1427:TQATCA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONIN RECEPTORS; BINDING-SITES; BRAIN; DISCRIMINATION; 5-HYDROXYTRYPTAMINE; 5-HT2-RECEPTORS; IDENTIFICATION;
Keywords:
CONDITIONED AVOIDANCE RESPONSE; SEROTONERGIC RECEPTORS; QUIPAZINE; KETANSERIN; PINDOLOL; TFMPP; SHUTTLE BOX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Alhaider et al., "THE QUIPAZINE-INCREASED AND TFMPP-INCREASED CONDITIONED AVOIDANCE-RESPONSE IN RATS - ROLE OF 5-HT1C 5-HT2 RECEPTORS/", Neuropharmacology, 32(12), 1993, pp. 1427-1432

Abstract

The role of serotonin (5-HT) in the acquisition of the conditioned avoidance response was investigated. The effects of different serotonin agonists and antagonists, administered prior to learning sessions, were studied in groups of naive rats using the two-way shuttle box. Quipazine, an agonist at 5-HT1B/1C/2 receptors, significantly increased avoidance responding in a dose-dependent manner (1.25-10 mg/kg, s.c.). The putative 5-HT1B/1C receptor agonist TFMPP (l-[m-triftuoromethylphenyl] piperazine) at doses of 1.25 and 2.5 mg/kg (s.c.), increased acquisition of conditioned avoidance but showed no significant difference from control at doses of 5 and 10 mg/kg. The 5-HT,A agonist, buspirone, significantly decreased acquisition of conditioned avoidance. Increased acquisition of conditioned avoidance induced by either quipazine or TFMPP was effectively antagonized by the mixed 5-HT1C/2. receptor antagonists, ketanserin (0.2 and 2 mg/kg, s.c.)and mianserin (1 mg/kg, s.c.). In Contrast, spiperone (5-HT1A/2 receptors antagonist: 0.2 mg/kg, s.c.) only inhibited the increased acquisition induced by TFMPP. On the other hand, the 5-HT1A/1B receptors antagonist, pindolol, failed to antagonize the increase in acquisition of conditioned avoidance causedby quipazine or TFMPP. These results suggest that quipazine increasesthe conditioned avoidance behaviour by an action that might be mediated through stimulation of 5-HT1C receptors. The acquisition of conditioned avoidance induced by TFMPP, which was blocked by ketanserin, mianserin and spiperone but not by pindolol, suggests the involvement of 5-HT1C/2 receptors in the action of TFMPP.

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Documento generato il 26/01/20 alle ore 01:09:42