Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INVOLVEMENT OF NK1 RECEPTORS IN SYNAPTIC TRANSMISSION IN THE GUINEA-PIG CELIAC GANGLION
Autore:
ZHAO FY; SAITO K; KONISHI S; GUO JZ; MURAKOSHI T; YOSHIOKA K; OTSUKA M;
Indirizzi:
TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL,BUNKYO KU TOKYO TOKYO 113 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL,BUNKYO KU TOKYO TOKYO 113 JAPAN SANKYO CORP LTD,BIOL RES LABS TOKYO TOKYO 140 JAPAN MITSUBISHI KASEI INST LIFE SCI TOKYO TOKYO 194 JAPAN
Titolo Testata:
Neuroscience research
fascicolo: 3, volume: 18, anno: 1993,
pagine: 245 - 248
SICI:
0168-0102(1993)18:3<245:IONRIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR MESENTERIC GANGLION; SUBSTANCE-P; SYMPATHETIC-GANGLIA; NEURONS; ANTAGONISTS; NEUROKININ; SEROTONIN; CAPSAICIN;
Keywords:
TACHYKININ; SUBSTANCE P; NEUROKININ A; TACHYKININ RECEPTOR; SLOW EPSP; CELIAC GANGLION; GUINEA PIG;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
F.Y. Zhao et al., "INVOLVEMENT OF NK1 RECEPTORS IN SYNAPTIC TRANSMISSION IN THE GUINEA-PIG CELIAC GANGLION", Neuroscience research, 18(3), 1993, pp. 245-248

Abstract

Using intracellular recording techniques, we examined the effects of tachykinin receptor agonists and antagonists on electrophysiologicallyidentified tonic neurons of the isolated guinea pig coeliac ganglion. In most of the tonic neurons, substance P (SP), neurokinin A (NKA) and/or senktide induced a depolarization. The effects of SP and NKA wereblocked by the NK1-selective antagonist, GR71251 (5 mu M), but not bythe NK2-selective antagonist, L659,877 (10 mu M), whereas the effect of senktide was not affected by these antagonists. The NK1-selective agonists, [Sar(9),Met(O)(2)(11)]SP and SP methyl ester, and the NK(3-)selective agonist, [MePhe(7)]neurokinin B, also evoked depolarizations in tonic neurons. By contrast, the NK2-selective agonists, [Nle(10)]NKA(4-10), [beta-Ala(8)]NKA(4-10) and GR64349, at 1 mu M each, did not evoke any significant depolarizing response. Repetitive electrical stimulation of the mesenteric nerves induced slow excitatory postsynaptic potentials (EPSPs) in the majority of tonic neurons, which were depressed by GR71251 (5 mu M). These results suggest that NK1 and NK3 receptors but not NK2 receptors are involved in the tachykinin-induced depolarization of tonic neurons, and that the NKA-induced response is due to the activation of NK1 receptors. This study also suggests the involvement of NK1 receptors in the slow EPSPs in tonic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:14:25