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Titolo:
DYSTROPHIN EXPRESSION IMPROVES MYOFIBER SURVIVAL IN MDX MUSCLE FOLLOWING INTRAMUSCULAR PLASMID DNA INJECTION
Autore:
DANKO I; FRITZ JD; LATENDRESSE JS; HERWEIJER H; SCHULTZ E; WOLFF JA;
Indirizzi:
UNIV WISCONSIN,WAISMAN CTR MENTAL RETARDAT & HUMAN DEV,DEPT PEDIAT,1500 HIGHLAND AVE MADISON WI 53705 UNIV WISCONSIN,WAISMAN CTR MENTAL RETARDAT & HUMAN DEV,DEPT PEDIAT MADISON WI 53705 UNIV WISCONSIN,WAISMAN CTR MENTAL RETARDAT & HUMAN DEV,DEPT MED GENETMADISON WI 53705 UNIV WISCONSIN,DEPT ANAT MADISON WI 53706
Titolo Testata:
Human molecular genetics
fascicolo: 12, volume: 2, anno: 1993,
pagine: 2055 - 2061
SICI:
0964-6906(1993)2:12<2055:DEIMSI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED MUSCULAR-DYSTROPHY; DIRECT GENE-TRANSFER; CENTRAL-NERVOUS-SYSTEM; MOUSE SKELETAL-MUSCLE; INVIVO; MICE; REGENERATION; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
I. Danko et al., "DYSTROPHIN EXPRESSION IMPROVES MYOFIBER SURVIVAL IN MDX MUSCLE FOLLOWING INTRAMUSCULAR PLASMID DNA INJECTION", Human molecular genetics, 2(12), 1993, pp. 2055-2061

Abstract

Expression of Becker-like and full-length human dystrophins was stable for at least 6 months in mdx mouse muscle following intramuscular plasmid DNA injection. Intramuscular injection of a single plasmid DNA encoding both luciferase and dystrophin resulted in stable luciferase expression for at least 2 months in mdx muscle, whereas injection of plasmid DNA encoding only luciferase did not result in stable luciferaseexpression. These results suggest that expression of either full-length or Becker-like dystrophins protects mdx mouse myofibers from degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:16:45