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Titolo:
IN-VIVO EVALUATION OF THE INHIBITORY CAPACITY OF HUMAN PLASMA ON EXOGENOUS SURFACTANT FUNCTION
Autore:
LACHMANN B; EIJKING EP; SO KL; GOMMERS D;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT ANESTHESIOL,ROOM EE 2393,POB 1738 3000 DRROTTERDAM NETHERLANDS
Titolo Testata:
Intensive care medicine
fascicolo: 1, volume: 20, anno: 1994,
pagine: 6 - 11
SICI:
0342-4642(1994)20:1<6:IEOTIC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; PULMONARY SURFACTANT; REPLACEMENT THERAPY; LUNG SURFACTANT; PREMATURE LAMBS; ARTIFICIAL SURFACTANT; NATURAL SURFACTANT; CLINICAL-TRIAL; GAS-EXCHANGE; PROTEIN;
Keywords:
ANIMAL MODEL; BLOOD GASES; RESPIRATORY FAILURE; EXOGENOUS SURFACTANT THERAPY; SURFACTANT INHIBITION; PLASMA PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
B. Lachmann et al., "IN-VIVO EVALUATION OF THE INHIBITORY CAPACITY OF HUMAN PLASMA ON EXOGENOUS SURFACTANT FUNCTION", Intensive care medicine, 20(1), 1994, pp. 6-11

Abstract

Objective: The adult respiratory distress syndrome (ARDS) and neonatal respiratory distress syndrome (RDS) are characterized by high permeability pulmonary edema which contains plasma-derived proteins inhibiting pulmonary surfactant function. Currently, discussion continues as to what dose of surfactant is required for treatment of these syndromes. Design: The purpose of this study was to investigate the amount of exogenous surfactant needed to overcome the inhibitory components in human plasma. Male adult rats suffering from respiratory failure due to surfactant depletion after whole-lung lavage received human plasma (4 ml/kg body weight) mixed with surfactant at different concentrations, intratracheally. Rats receiving surfactant only at different concentrations served as controls. Blood gas analysis was performed. Measurements and results: It was demonstrated that plasma (4 ml/kg approximate to 273 mg plasma proteins/kg) mixed with surfactant at 300 mg/kg was able to increase and maintain PaO2 normal values. Plasma mixed with surfactant at 100 mg/kg, after initial restoration of blood gases, showed deterioration of PaO2 values. Plasma mixed with surfactant at a dose of 50 mg/kg did not improve PaO2 whereas surfactant at 50 mg/kg, without plasma, restored blood gases to pre-lavage values. Conclusion: It isconcluded that approximately 1 mg surfactant phospholipids is required to overcome the inhibitory effect of approximately 1 mg plasma proteins. For clinical practice this means that an excess of surfactant should be given, or repeatedly be substituted (''titrated'') at low concentrations, until blood gases improve.

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Documento generato il 05/07/20 alle ore 03:04:01