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Titolo:
DEPLETION OF SECRETORY GRANULES FROM THE FELINE PAROTID-GLAND - ACTION OF NANC TRANSMITTERS PER SE
Autore:
EKSTROM J; ASZTELY A; HELANDER HF; TOBIN G;
Indirizzi:
UNIV GOTEBORG,DEPT PHARMACOL,MEDICINAREGATAN 7 S-41390 GOTHENBURG SWEDEN ASTRA HASSLE AB MOLNDAL SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 150, anno: 1994,
pagine: 83 - 88
SICI:
0001-6772(1994)150:1<83:DOSGFT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; PROTEIN SECRETION; STIMULATION; PEPTIDE; CAT;
Keywords:
NANC-TRANSMITTERS; PAROTID GLAND; SECRETORY GRANULES; VASOACTIVE INTESTINAL PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Ekstrom et al., "DEPLETION OF SECRETORY GRANULES FROM THE FELINE PAROTID-GLAND - ACTION OF NANC TRANSMITTERS PER SE", Acta Physiologica Scandinavica, 150(1), 1994, pp. 83-88

Abstract

A parotid acinar degranulation of approximately 60 and 40% was observed in cats under pentobarbitone anaesthesia after a 90-min period of continuous stimulation of the parasympathetic auriculo-temporal nerve at 10 Hz in the absence and presence of atropine, respectively. Atropine completely abolished the large fluid response of the gland to the nerve stimulation. In the non-atropinized cats, bethanechol, infused into the carotid artery at a dose rate evoking a salivary flow similar tothat in response to parasympathetic nerve stimulation, caused an acinar degranulation of approximately 25% and acinar vacuolation. Vasoactive intestinal peptide (VIP;0.5 mu g kg(-1) min(-1) also infused into the carotid artery for 90 min) caused an acinar degranulation of the same magnitude as the parasympathomimetic drug but the peptide did not give rise to any fluid secretion or vacuole formation. The experiments were performed in the presence of alpha- and beta-adrenoceptor blockers. Thus, in parotid glands of the cat, producing no overt secretion offluid, non-adrenergic, non-cholinergic (NANC) mechanisms may be at work causing exocytosis of the acinar granules. These mechanisms are also likely to contribute to the secretion of granules in response to parasympathetic nerve activity in the absence of blockade of the classical autonomic receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:34:43