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Titolo:
INTERACTION BETWEEN L-GLUTAMATE AND ETHANOL ON THE CENTRAL DEPRESSANTPROPERTIES OF ETHANOL IN MICE
Autore:
FERKO AP;
Indirizzi:
HAHNEMANN UNIV,SCH MED,DEPT PHARMACOL,BROAD & VINE PHILADELPHIA PA 19102
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 47, anno: 1994,
pagine: 351 - 354
SICI:
0091-3057(1994)47:2<351:IBLAEO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; INDUCED SLEEP TIME; TAURINE ANTAGONIST; GABAERGIC TRANSMISSION; HIPPOCAMPAL-NEURONS; RELEASE; CORTEX; H-3-GABA; CYSTEINE; ENHANCE;
Keywords:
ETHANOL; L-GLUTAMATE; BICUCULLINE; CNS DEPRESSION; LOSS OF RIGHTING REFLEX; GABA; SLEEP TIME; GLUTAMIC ACID;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.P. Ferko, "INTERACTION BETWEEN L-GLUTAMATE AND ETHANOL ON THE CENTRAL DEPRESSANTPROPERTIES OF ETHANOL IN MICE", Pharmacology, biochemistry and behavior, 47(2), 1994, pp. 351-354

Abstract

The effect of L-glutamate to alter ethanol-induced central depressionwas studies in male Swiss-Webster mice. The duration loss of the righting reflex (LORR) was used as a measurement of CNS depression. Mice were injected (IP) with ethanol (4.0 g/kg), which caused them to lose the righting reflex. After mice regained the righting reflex following ethanol injection (IP), they were immediately injected (ICV) with saline or L-glutamate (1, 15, or 25 mu mol/kg). L-Glutamate induced a return to the LORR within 60 s after ICV injection of drug. When L-glutamate was administered (ICV) in the absence of ethanol, no significant loss of the righting occurred. In other experiments, DL-2-amino-5-phosphonovaleric acid (APV), a competitive inhibitor of NMDA, was given ICV with L-glutamate in the presence of ethanol. APV did not significantlyantagonize the interaction between ethanol and L-glutamate. When bicuculline methiodide, a GABA antagonists, was administered with L-glutamate (ICV), bicuculline methiodide reduced the effect of L-glutamate toproduce a return to the LORR in the presence of ethanol. These data indicate the L-glutamate, an excitatory amino acid neurotransmitter, can enhance the central depressant action of ethanol. It appears that aninteraction between the GABAergic and glutamatergic systems may be involved in ethanol intoxication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:02:24