Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF DEXFENFLURAMINE ON SACCHARIN DRINKING - BEHAVIORAL AND PHARMACOLOGICAL STUDIES
Autore:
HIGGINS GA; TOMKINS DM; POULOS CX; SELLERS EM;
Indirizzi:
UNIV HERTFORDSHIRE,DIV BIOSCI,GLAXO UNIT BEHAV PSYCHOPHARMACOL,COLL LANE HATFIELD HERTS AL10 9AB ENGLAND ADDICT RES FDN TORONTO M5S 2S1 ON CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO ON CANADA UNIV TORONTO,DEPT PSYCHOL TORONTO ON CANADA UNIV TORONTO,DEPT MED TORONTO ON CANADA
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 47, anno: 1994,
pagine: 307 - 315
SICI:
0091-3057(1994)47:2<307:EODOSD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-FENFLURAMINE; FOOD-INTAKE; FEEDING-BEHAVIOR; SATIETY SEQUENCE; 5-HT1 RECEPTORS; SATIATED RATS; D-AMPHETAMINE; SWEET TASTE; FLUOXETINE; SEROTONIN;
Keywords:
DEXFENFLURAMINE; SACCHARIN; BEHAVIORAL SATIETY SEQUENCE; 5-HT; RAT; PALATABILITY; METERGOLINE; ANTICIPATORY BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Higgins et al., "EFFECT OF DEXFENFLURAMINE ON SACCHARIN DRINKING - BEHAVIORAL AND PHARMACOLOGICAL STUDIES", Pharmacology, biochemistry and behavior, 47(2), 1994, pp. 307-315

Abstract

We have previously reported that the 5-hydroxytryptamine (5-HT) releaser/reuptake blocker dexfenfluramine suppresses voluntary ethanol intake. To further analyse the generality of these findings, in the present study we examined the effect of equivalent doses of dexfenfluramine (0.5-2.5 mg/kg) on the intake of another preferred fluid, saccharin. Saccharin was made available for 2 h daily across a wide concentration range chosen to promote varying degrees of intake. Following stable levels of intake, the behaviour of vehicle-pretreated rats was assessed immediately prior to (anticipatory/preparatory phase) and during (consumatory phase) saccharin access. These behaviours were compared and contrasted with those produced following dexfenfluramine pretreatment atthe optimally preferred saccharin concentration (0.2%). In a preliminary study the effects of various 5-HT antagonists were also examined against the dexfenfluramine response. The present results suggest that dexfenfluramine produced a dose-related suppression of saccharin intake at doses similar to those which reduced ethanol intake. However, themagnitude of this suppression was similar across each saccharin concentration. Behavioural analysis indicated that the profile of the dexfenfluramine (0.5- and 1-mg/kg doses only) suppression of the 0.2% solution was similar to that observed in vehicle-pretreated rats presented with saccharin solutions of lesser palatability to this concentration. Pharmacological studies indicated a 5-HT1 (non-5-HT1c) receptor involvement in the dexfenfluramine response. These studies imply that at certain doses dexfenfluramine may produce a subtle alteration in the motivation to consume a preferred fluid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:27:09