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Titolo:
COMPARISON OF THE NPY RECEPTORS MEDIATING VASOCONSTRICTION OF THE GUINEA-PIG UTERINE ARTERY AND THORACIC VENA-CAVA USING A RANGE OF NPY ANALOGS
Autore:
MORRIS JL; SABESAN S;
Indirizzi:
FLINDERS UNIV S AUSTRALIA,CTR NEUROSCI,BOX 2100 ADELAIDE SA 5001 AUSTRALIA FLINDERS UNIV S AUSTRALIA,SCH MED,DEPT ANAT & HISTOL ADELAIDE SA 5001AUSTRALIA
Titolo Testata:
Neuropeptides
fascicolo: 1, volume: 26, anno: 1994,
pagine: 21 - 28
SICI:
0143-4179(1994)26:1<21:COTNRM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y RECEPTORS; APPLIED ACETYLCHOLINE; INHIBITS RELAXATION; VAGAL-STIMULATION; SMALL-INTESTINE; SINUS VENOSUS; CO-EXISTENCE; RAT; CONTRACTION; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Morris e S. Sabesan, "COMPARISON OF THE NPY RECEPTORS MEDIATING VASOCONSTRICTION OF THE GUINEA-PIG UTERINE ARTERY AND THORACIC VENA-CAVA USING A RANGE OF NPY ANALOGS", Neuropeptides, 26(1), 1994, pp. 21-28

Abstract

The ability of analogues of neuropeptide Y (NPY) to produce direct vasoconstriction, or to antagonize NPY constrictions, was examined in isolated segments of the thoracic vena cava and the uterine artery of guinea-pigs, where NPY mediates a slow phase of sympathetic vasoconstriction. [Leu31,Pro34]NPY, NPY(13-36) and NPY(18-36) all contracted the uterine artery and the vena cava. Contractions produced by [Leu31,Pro34]NPY were similar in time course to those produced by porcine NPY (pNPY), although contractions produced by NPY(13-36) or NPY(18-36) typically were slower than pNPY contractions. In both vessels the order of potency of the agonists was pNPY greater-than-or-equal-to [Leu31,Pro34]NPY > NPY(13-36) > NPY(18-36). High concentrations (10(-5) mol.l-1) of pNPY or [Leu31,Pro34]NPY produced desensitization of contractions of the uterine artery produced by NPY(13-36). The reported NPY receptor antagonists, PYX-1 and PYX-2 (5 x 10(-6) mol.l-1), slightly reduced (by 21-47%) the magnitude of constrictions produced by exogenous pNPY (1-3x 10(-8) mol.l-1) in both the uterine artery and the vena cava. Theseresults show that the NPY receptors mediating slow sympathetic vasoconstriction of both the uterine artery and the vena cava are likely to be predominantly Y1 receptors, despite differences between the adrenoceptors mediating sympathetic responses in the two blood vessels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:33:34