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Titolo:
THE STABILITY OF PLASMA GROWTH-HORMONE AND MHPG RESPONSES TO REPEATEDCLONIDINE CHALLENGE IN NORMAL MALES
Autore:
TRESTMAN RL; COCCARO EF; LAWRENCE T; KNOTT P; GABRIEL SM; SIEVER LJ;
Indirizzi:
VET AFFAIRS MED CTR,PSYCHIAT SERV,116A BRONX NY 10468 CUNY MT SINAI SCH MED NEW YORK NY 10029 MED COLL PENN PHILADELPHIA PA 19129
Titolo Testata:
Psychoneuroendocrinology
fascicolo: 1, volume: 19, anno: 1994,
pagine: 13 - 20
SICI:
0306-4530(1994)19:1<13:TSOPGA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRESSED MALE-PATIENTS; ENDOGENOUS-DEPRESSION; DISORDER PATIENTS; DESIPRAMINE; RELEASE; MANIA; TESTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Trestman et al., "THE STABILITY OF PLASMA GROWTH-HORMONE AND MHPG RESPONSES TO REPEATEDCLONIDINE CHALLENGE IN NORMAL MALES", Psychoneuroendocrinology, 19(1), 1994, pp. 13-20

Abstract

Clonidine is a centrally acting alpha2-adrenergic agonist used in many psychiatric studies to assess adrenergic functioning. The short- andlong-term stability of plasma growth hormone (GH) and plasma 3-methoxy-4-hydroxy phenylglycol (MHPG) responses to clonidine (2 mug/kg IV) over a 60-min period were assessed in subsets of 13 male normal controls on 2 consecutive days (Study A; n = 11) and on 2 days separated by several months (Study B; n = 11). In Study A, no significant differences between consecutive days were found in either baseline plasma GH or MHPG or their responses to clonidine. The 60 minute plasma GH responses between consecutive days were highly correlated (r = 0.75, n = 11, p< .001), while the 60 min plasma MHPG responses were not. In Study B.no significant differences in baseline plasma GH or MHPG, or their responses to clonidine challenge, were found between the 2 test days. However, neither the plasma GH responses nor the plasma MHPG responses to clonidine at 60 min correlated significantly between the 2 study days separated by several months. Both in Study A and in Study B, 8 of 11subjects had a stable GH response to clonidine across both study dayswhen defined dichotomously (blunted < 4 ng/ml; otherwise, not blunted). These results suggest that the plasma GH response and plasma MHPG response to clonidine are unaffected by repeat clonidine challenge separated by 24 h, and that the plasma GH response to clonidine may be more stable over time than the plasma MHPG response to clonidine.

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Documento generato il 19/01/20 alle ore 05:57:35