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Titolo:
MODE OF CELL-PROLIFERATION IN THE DEVELOPING MOUSE NEOCORTEX
Autore:
TAKAHASHI T; NOWAKOWSKI RS; CAVINESS VS;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL BOSTON MA 02114 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL PISCATAWAY NJ 08854
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 1, volume: 91, anno: 1994,
pagine: 375 - 379
SICI:
0027-8424(1994)91:1<375:MOCITD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CEREBRAL-CORTEX; VENTRICULAR ZONE; PRECURSOR CELLS; STEM-CELLS; NEURONS; GENERATION; EXPRESSION; MIGRATION; MONKEY; CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Takahashi et al., "MODE OF CELL-PROLIFERATION IN THE DEVELOPING MOUSE NEOCORTEX", Proceedings of the National Academy of Sciences of the United Statesof America, 91(1), 1994, pp. 375-379

Abstract

There are two proliferative populations in the developing cerebral wall: the pseudostratified ventricular epithelium (PVE) and the secondary proliferative population (SPP). The present experiments provide on embryonic day 14 (E14) in the mouse direct measures of the values for the proportions of daughter cells that continue to proliferate (proliferative, P fraction, or P) and for those that leave the cell cycle (quiescent, Q fraction, or Q; Q = 1 - P) for both of these populations. The range of values of P for the PVE, 0.62-0.66, would provide for the relatively low rate of neuronal output and for an expansion of the proliferative population appropriate for E14. The even higher values of P for the SPP, 0.73-1.0, would expand this population rapidly in preparation for the high glial cell output to occur later in cerebral histogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:14:47