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Titolo:
PRODUCTION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-2 BY SEPARATE, PHENOTYPICALLY DIFFERENT LEUKEMIA AND HUMAN T-CELL LYMPHOTROPIC VIRUS-1-TRANSFORMED T-CELL CLONES
Autore:
HOLAN V; MINOWADA J;
Indirizzi:
ACAD SCI CZECH REPUBL,INST MOLEC GENET,FLEMINGOVO NAM 2 CS-16637 PRAGUE 6 CZECH REPUBLIC HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA OKAYAMA JAPAN
Titolo Testata:
Immunology and cell biology
, volume: 71, anno: 1993,
parte:, 6
pagine: 509 - 515
SICI:
0818-9641(1993)71:<509:POIAIB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELPER CELL; EXPRESSION; IL-2; LYMPHOCYTES; LYMPHOKINE; IL-1-ALPHA; RECEPTOR; PATHWAYS; LINE;
Keywords:
INTERLEUKIN-1; INTERLEUKIN-2; IMMUNOPHENOTYPE MARKERS; T CELL LINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
V. Holan e J. Minowada, "PRODUCTION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-2 BY SEPARATE, PHENOTYPICALLY DIFFERENT LEUKEMIA AND HUMAN T-CELL LYMPHOTROPIC VIRUS-1-TRANSFORMED T-CELL CLONES", Immunology and cell biology, 71, 1993, pp. 509-515

Abstract

The relationship between interleukin-1 (IL-1) and interleukin-2 (IL-2) production and immunophenotype marker profiles was studied in a panel of 29 leukaemia and human T cell lymphotropic virus-1 (HTLV-1)-transformed T cell lines. Culture supernatants from six of the 29 T cell lines tested increased IL2 production by the MOLT-16 cell line in a manner similar to that of rIL-1 alpha or rIL-1 beta. The enhancing activity in the cell culture supernatants was inhibited by antibody against IL-1 alpha. Anti-IL-1 beta antibody had no inhibitory effect. All the cell lines producing IL-1 alpha had characteristics of activated matureT cells. They were terminal deoxyribonucleotidyl transferase (TdT)(-), CD4(+), CD8(-), HLA-DR(+) and all were strongly positive for IL-2R alpha (Tac antigen) expression. However, none of the IL-1 alpha producing cell lines secreted detectable IL-2. A significant quantity of IL-2was found, after stimulation with phytohaemagglutinin, in supernatants from nine of the 29 cell lines tested. The majority of IL-2 producing cell lines originated from less mature, non-activated T cells, as they were characterized by the expression of TdT, lack of HLA-DR antigens and > 50% had no detectable IL2R alpha. The results thus show that separate, phenotypically different leukaemia and HTLV-1-transformed T cell clones produce IL-1 alpha and IL-2. While IL-1 alpha production isexclusively confined to the cell lines having the phenotype of activated mature T cells, the IL-2 producing cell lines have much more diverse origins in terms of their stage of maturation.

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Documento generato il 27/11/20 alle ore 15:56:17