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Titolo:
THE UNIQUE EFFECT OF METHIOTHEPIN ON THE TERMINAL SEROTONIN AUTORECEPTOR IN THE RAT HYPOTHALAMUS COULD BE AN EXAMPLE OF INVERSE AGONISM
Autore:
MORET C; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81106 CASTRES FRANCE PIERRE FABRE RES CTR,DIV NEUROBIOL F-81100 CASTRES FRANCE
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 7, anno: 1993,
pagine: 331 - 337
SICI:
0269-8811(1993)7:4<331:TUEOMO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN CORTEX SLICES; ADRENOCEPTOR-MEDIATED MODULATION; LYSERGIC-ACID DIETHYLAMIDE; 5-HYDROXYTRYPTAMINE RELEASE; 5-HT AUTORECEPTOR; ADENYLATE-CYCLASE; RECEPTORS; HIPPOCAMPUS; ANTAGONISTS; NOREPINEPHRINE;
Keywords:
TERMINAL SEROTONIN AUTORECEPTOR; RELEASE; METHIOTHEPIN; ANTAGONIST; INVERSE AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C. Moret e M. Briley, "THE UNIQUE EFFECT OF METHIOTHEPIN ON THE TERMINAL SEROTONIN AUTORECEPTOR IN THE RAT HYPOTHALAMUS COULD BE AN EXAMPLE OF INVERSE AGONISM", J PSYCHOPH, 7(4), 1993, pp. 331-337

Abstract

Slices of rat hypothalamus were pre-incubated with [H-3] g-hydroxytryptamine ([H-3]5-HT), then superfused continuously and twice stimulatedelectrically. The effects of methiothepin, metergoline and alprenolol, all considered to be terminal 5-HT autoreceptor antagonists (although they also act at a number of other receptors), were studied. The stimulation-evoked overflow of tritium was increased by methiothepin in aconcentration-dependent manner. The slight enhancing effect of alprenolol was not concentration dependent and metergoline, at concentrations which did not modify spontaneous outflow, was devoid of effect on evoked tritium overflow. The concentration-dependent inhibition by the terminal 5-HT autoreceptor agonist, lysergic acid diethylamide (LSD), of the electrically induced release of [H-3]5-HT was antagonized by methiothepin, alprenolol and metergoline. The stimulatory effect of methiothepin on tritium release was diminished by metergoline and by alprenolol at a concentration which slightly enhanced the evoked overflow of[H-3]5-HT when given alone. Thus methiothepin induced an effect opposite to that of an agonist, in contrast to alprenolol and metergoline which under our conditions had no effect by themselves but reduced the effect of an agonist. In addition, the stimulating effect of methiothepin on release was reversed by two terminal 5-HT autoreceptor antagonists, alprenolol and metergoline. These results are consistent with methiothepin being an inverse agonist at the terminal 5-HT autoreceptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:04:48