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Titolo:
EFFECTS OF CORTISOL ON HEPATIC CARBOHYDRATE-METABOLISM AND RESPONSIVENESS TO HORMONES IN THE SEA RAVEN, HEMITRIPTERUS-AMERICANUS
Autore:
VIJAYAN MM; FOSTER GD; MOON TW;
Indirizzi:
FAC AGR SCI,DEPT ANIM SCI,248 2357 MAIN MALL VANCOUVER V6T 1Z4 BC CANADA HUNTSMAN MARINE SCI CTR ST ANDREWS E0G 2X0 NB CANADA UNIV OTTAWA,OTTAWA CARLETON INST BIOL,DEPT BIOL OTTAWA K1N 6N5 ONTARIO CANADA
Titolo Testata:
Fish physiology and biochemistry
fascicolo: 4, volume: 12, anno: 1993,
pagine: 327 - 335
SICI:
0920-1742(1993)12:4<327:EOCOHC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT ONCORHYNCHUS-MYKISS; ANGUILLA-ANGUILLA L; RAINBOW-TROUT; SALVELINUS-FONTINALIS; NUTRITIONAL STATE; GROWTH-HORMONE; COHO SALMON; BROOK CHARR; 5'-MONODEIODINASE ACTIVITY; ISOLATED HEPATOCYTES;
Keywords:
CORTISOL; SEA RAVEN; TELEOSTS; HEMITRIPTERUS-AMERICANUS; GLUCONEOGENESIS; GLYCOGENOLYSIS; METABOLISM; HEPATOCYTES; INSULIN; EPINEPHRINE; GLUCAGON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Vijayan et al., "EFFECTS OF CORTISOL ON HEPATIC CARBOHYDRATE-METABOLISM AND RESPONSIVENESS TO HORMONES IN THE SEA RAVEN, HEMITRIPTERUS-AMERICANUS", Fish physiology and biochemistry, 12(4), 1993, pp. 327-335

Abstract

The sea raven, Hemitripterus americanus, is a sit-and-wait, low metabolic rate, marine teleost. The objective of this study was to determine i) whether cortisol implantation (50 mg.kg-1) for 7 days altered hepatocyte metabolism, and hepatocyte responsiveness to epinephrine, glucagon and insulin, and ii) whether 8 weeks of food-deprivation modifiedthe above response. Cortisol implantation significantly increased hepatocyte total glucose production and oxidation from alanine compared to the sham group. There was no cortisol effect on glycogen breakdown, suggesting that the activation of other pathways, including gluconeogenesis, are required to account for the increased glucose production. Epinephrine-mediated (10(-5)M) glycogen breakdown and insulin-mediated (10(-8)M) total glucose production were enhanced in hepatocytes of cortisol implanted sea ravens, but there were no change in any glucagon (10(-7)M) effects. The enhanced glycogen breakdown in the absence of similar increases in total glucose production with epinephrine indicatesmobilization of carbohydrate reserves for endogenous use by the liver. Food-deprivation for 8 weeks significantly decreased condition factor, plasma cortisol concentration and liver glycogen content in the searaven, but had no effect on plasma glucose concentration. Hepatocyte total glucose production and flux rates from alanine increased significantly with food-deprivation. Moreover, food-deprivation increased responsiveness of total hepatocyte glucose production to the actions of glucagon and insulin, but not to epinephrine; none of these effects were modified by cortisol implantation. Our results indicate that cortisol in the sea raven exerts both a direct and an indirect or permissive effect on hepatocyte metabolism by modifying hepatocyte responsivenessto epinephrine and insulin stimulation. Cortisol implantation did notmodify the effects of glucagon or food-deprivation in this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:38:24