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Titolo:
LISINOPRIL VERSUS HYDROCHLOROTHIAZIDE IN MILD-TO-MODERATE SYSTOLIC DIASTOLIC OR ISOLATED SYSTOLIC HYPERTENSION IN THE ELDERLY
Autore:
DALPALU C; ROSEI EA; BOSSINI A; BUONINCONTI R; DESTE D; ECARI M; PICA B; FORTE PL; INNOCENTI P; PARRINELLO A; PORCELLATI C; ROMANELLI G; SCARPA R; TIMIO M;
Indirizzi:
MERCK SHARP & DOHME SPA,VIA G FABBRONI 6 I-00191 ROME ITALY MERCK SHARP & DOHME SPA,VIA G FABBRONI 6 I-00191 ROME ITALY UNIV PADUA,MED CLIN 1 I-35100 PADUA ITALY UNIV BRESCIA,MED CLIN 1 BRESCIA ITALY UNIV ROME,POLICLIN UMBERTO 1,SERV IPERTENS ARTERIOSA I-00161 ROME ITALY UNIV NAPLES,FAC 1,CTR IPERTENS ARTERIOSA CLIN MED 1 I-80138 NAPLES ITALY CIV HOSP MIRANO,SERV CARDIOL MIRANO ITALY MSD ITALY,CLIN RES DEPT ROME ITALY HOSP ROVIGO,DIV GERIAT ROVIGO ITALY CIV HOSP CARRARA CARRARA ITALY CIV HOSP LEGNAGO,DIV MED LEGNAGO ITALY SILVESTRINI HOSP PERUGIA,DIV MED PERUGIA ITALY HOSP CHIOGGIA,DIV GERIATR CHIOGGIA ITALY CIV HOSP FOLIGNO FOLIGNO ITALY
Titolo Testata:
Current therapeutic research
fascicolo: 6, volume: 54, anno: 1993,
pagine: 779 - 787
SICI:
0011-393X(1993)54:6<779:LVHIMS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTER; PATIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C. Dalpalu et al., "LISINOPRIL VERSUS HYDROCHLOROTHIAZIDE IN MILD-TO-MODERATE SYSTOLIC DIASTOLIC OR ISOLATED SYSTOLIC HYPERTENSION IN THE ELDERLY", Current therapeutic research, 54(6), 1993, pp. 779-787

Abstract

This double-blind, randomized, multicenter study was designed to compare the efficacy and tolerability of lisinopril and hydrochlorothiazide (HCTZ) in elderly patients (greater-than-or-equal-to 65 years old) with either mild-to-moderate systolic/diastolic hypertension (SDBP greater-than-or-equal-to 95 less-than-or-equal-to 120 mmHg) or isolated systolic hypertension (SSBP > 160 mmHg, SDBP < 90 mmHg) and creatinine clearance levels greater-than-or-equal-to 30 ml/min. At the end of a 2-week placebo run-in period, 96 patients were randomized in a 1:1 mode to receive either lisinopril 10 mg/day or HCTZ 12.5 mg/day. During the12-week study, the doses of lisinopril and HCTZ were doubled every 4 weeks for nonresponders to a maximum of 40 and 50 mg/day, respectively. A positive response was defined as sitting diastolic blood pressure less-than-or-equal-to 90 mmHg for systolic/diastolic hypertension and as sitting systolic blood pressure less-than-or-equal-to 140 mmHg for isolated systolic hypertension. Mean decreases from baseline in systolic and diastolic blood pressures were significant (P less-than-or-equal-to 0.01) in both treatment groups. Both drugs were generally well tolerated; however, patients treated with HCTZ experienced more adverse effects. Moreover, mean serum potassium levels decreased significantlyin the HCTZ group. No serious adverse events were reported in either group. Lisinopril has been shown to be an effective, well-tolerated angiotensin-converting enzyme inhibitor in elderly patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:03:56