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Titolo:
POTASSIUM-INDUCED DEPOLARIZATION STIMULATES SOMATOSTATIN GENE-EXPRESSION IN CULTURED FETAL-RAT CEREBROCORTICAL CELLS
Autore:
CACICEDO L; TOLON RM; LORENZO MJ; LOPEZ J; FRANCO FS;
Indirizzi:
HOSP RAMON & CAJAL,SERV ENDOCRINOL,CARRETERA COLMENAR KM 9 E-28034 MADRID SPAIN INST CARLOS III,CTR NACL INVEST CLIN MADRID SPAIN
Titolo Testata:
Journal of pediatric endocrinology
fascicolo: 3-4, volume: 6, anno: 1993,
pagine: 219 - 223
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROENKEPHALIN MESSENGER-RNA; NERVE GROWTH-FACTOR; MEMBRANE DEPOLARIZATION; BRAIN-CELLS; TRANSCRIPTION; FOS; NEURONS; PROTEIN; CREB;
Keywords:
SOMATOSTATIN GENE REGULATION; CHRONIC DEPOLARIZATION; POTASSIUM; POTASSIUM-INDUCED SS GENE EXPRESSION; BRAIN SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L. Cacicedo et al., "POTASSIUM-INDUCED DEPOLARIZATION STIMULATES SOMATOSTATIN GENE-EXPRESSION IN CULTURED FETAL-RAT CEREBROCORTICAL CELLS", Journal of pediatric endocrinology, 6(3-4), 1993, pp. 219-223

Abstract

The stimulatory effect of potassium depolarization upon somatostatin mRNA (SS mRNA) levels in primary cultures of fetal cerebrocortical cells was analyzed. Depolarizing stimuli, such as 56 mM K+ concentration for 24 hours, elicited an increase in immunoreactive somatostatin (IR-SS) release to the media and SS mRNA levels, suggesting that somatostatin secretion can be coupled to SS mRNA accumulation. These changes were inhibited by the Ca2+ channel antagonist verapamil (VPM). In contrast, Na+ channel blockade by tetrodotoxin (TTX) did not modify the 24 hpotassium-induced increase in SS mRNA. These results suggest that theinduction of SS mRNA expression by K+ involves the modulation of calcium ion channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:24:24