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Titolo:
AMPLIFYING EFFECT OF SUMATRIPTAN ON NORADRENALINE VENOCONSTRICTION INMIGRAINE PATIENTS
Autore:
PANCONESI A; FRANCHI G; ANSELMI B; CURRADI C; TARQUINI B;
Indirizzi:
UNIV FLORENCE,CTR HEADACHE,INST INTERNAL MED 4,V PIERACCINI 18 I-30134 FLORENCE ITALY
Titolo Testata:
Cephalalgia
fascicolo: 6, volume: 13, anno: 1993,
pagine: 383 - 388
SICI:
0333-1024(1993)13:6<383:AEOSON>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMIGRAINE DRUG SUMATRIPTAN; CEREBRAL BLOOD-FLOW; 5-HT1-LIKE RECEPTOR; 5-HYDROXYTRYPTAMINE; ERGOTAMINE; ARTERIES; PHARMACOLOGY; GR43175; VASOCONSTRICTOR; CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Panconesi et al., "AMPLIFYING EFFECT OF SUMATRIPTAN ON NORADRENALINE VENOCONSTRICTION INMIGRAINE PATIENTS", Cephalalgia, 13(6), 1993, pp. 383-388

Abstract

The venoconstrictive activity of sumatriptan and its interaction withnoradrenaline (NA)- and 5-hydroxytryptamine (5HT) venoconstriction was studied in vivo in the hand vein of migraineurs. Sumatriptan, injected at increasing doses into the vein, caused local venoconstriction after a 500 mu g dose, comparable to that induced by 0.5-1 mu g of 5HT. This venoconstriction was completely inhibited by low doses of ketanserin (5 mu g). Subcutaneous sumatriptan (6 mg) provoked a minor increase in vein tone, lasting less than 30 min. Non-venoconstrictive doses of sumatriptan (10-100 mu g), injected in the hand vein, produced an amplification of NA-venoconstriction but not of 5HT-induced venoconstriction. A similar increased effect was displayed by subcutaneous sumatriptan (6 mg) for at least 1 h. Sumatriptan appears to cause peripheral venoconstriction only at high doses locally applied (in the hand vein), by acting on 5HT, receptors. Clinical subcutaneous doses (6 mg) do not show significant venoconstrictive effects. The amplifying effect onNA venoconstriction, also caused by 5HT, ergotamine and dihydroergotamine in human cranial arteries, may be important in explaining the therapeutic action of sumatriptan in migraine attacks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:12:30