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Titolo:
THE IRREGULAR CHIASM C-ROUGHEST LOCUS OF DROSOPHILA, WHICH AFFECTS AXONAL PROJECTIONS AND PROGRAMMED CELL-DEATH, ENCODES A NOVEL IMMUNOGLOBULIN-LIKE PROTEIN
Autore:
RAMOS RGP; IGLOI GL; LICHTE B; BAUMANN U; MAIER D; SCHNEIDER T; BRANDSTATTER JH; FROHLICH A; FISCHBACH KF;
Indirizzi:
ALBERT LUDWIGS UNIV,INST BIOL 3 D-79104 FREIBURG GERMANY ALBERT LUDWIGS UNIV,INST BIOL 3 D-79104 FREIBURG GERMANY BIOZENTRUM BASEL CH-4056 BASEL SWITZERLAND
Titolo Testata:
Genes & development
fascicolo: 12B, volume: 7, anno: 1993,
pagine: 2533 - 2547
SICI:
0890-9369(1993)7:12B<2533:TICCLO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING OPTIC LOBES; GROWTH CONE GUIDANCE; ADHESION MOLECULES; CAENORHABDITIS-ELEGANS; NEURONAL RECOGNITION; NUCLEOTIDE-SEQUENCE; SURFACE RECOGNITION; NEURAL DEVELOPMENT; GENETIC-ANALYSIS; FASCICLIN-II;
Keywords:
CELL ADHESION; IMMUNOGLOBULIN SUPERFAMILY; DM-GRASP; OPTIC CHIASMS; STRUCTURAL BRAIN MUTANT; VERTICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
R.G.P. Ramos et al., "THE IRREGULAR CHIASM C-ROUGHEST LOCUS OF DROSOPHILA, WHICH AFFECTS AXONAL PROJECTIONS AND PROGRAMMED CELL-DEATH, ENCODES A NOVEL IMMUNOGLOBULIN-LIKE PROTEIN", Genes & development, 7(12B), 1993, pp. 2533-2547

Abstract

The axonal projection mutations irregular chiasm C of Drosophila melanogaster comap and genetically interact with the roughest locus, whichis required for programmed cell death in the developing retina. We cloned the genomic region in 3C5 by transposon tagging and identified a single transcription unit that produces a major, spatially and temporally regulated mRNA species of approximately 5.0 kb. Postembryonic expression is strong in the developing optic lobe and in the eye imaginal disc. The gene encodes a transmembrane protein of 764 amino acids withfive extracellular immunoglobulin-like domains and similarity to the chicken axonal surface glycoprotein DM-GRASP/SC1/BEN. Both known irreCalleles reduce the level of transcription, whereas the roughest(CT) mutation disrupts the intracellular domain of the protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:59:38