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Titolo:
EFFECTS OF DRUGS ACTIVE AT ADENOSINE RECEPTORS ON STRESS-INDUCED ANALGESIA IN MICE
Autore:
ZARRINDAST MR; SABETKASAI M; KHAKPOUR S;
Indirizzi:
TEHRAN UNIV,SCH MED,DEPT PHARMACOL,POB 13145 784 TEHRAN IRAN
Titolo Testata:
Archives internationales de pharmacodynamie et de therapie
, volume: 325, anno: 1993,
pagine: 51 - 60
SICI:
0003-9780(1993)325:<51:EODAAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; PHENYLISOPROPYL-ADENOSINE; CYCLIC-AMP; MORPHINE; ANTINOCICEPTION; NOCICEPTION; ACCUMULATION; INVOLVEMENT; CAFFEINE; NALOXONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Zarrindast et al., "EFFECTS OF DRUGS ACTIVE AT ADENOSINE RECEPTORS ON STRESS-INDUCED ANALGESIA IN MICE", Archives internationales de pharmacodynamie et de therapie, 325, 1993, pp. 51-60

Abstract

Mice were stressed by swimming for 3 min in water at 20-degrees-C andantinociception was assessed by the tail-flick test. The stress-induced antinociception was potentiated by intraperitoneal administration of different doses of theophylline. The effect of the drug was dose-dependent. 5'-N-Ethylcarboxamidoadenosine administration also increased the stress response dose-dependently. N6-Phenyl-isopropyladenosine decreased the antinociception induced by swim-stress as well as after stress plus theophylline. Administration of dipyridamole caused a decreaseof antinociception induced by stress or stress plus theophylline. It may be concluded that activation of A2 adenosine receptors increased whereas activation of A1 adenosine sites decreased the stress-induced antinociception. The responses of A2 or A1 activation may be irrelevantto changes in cAMP levels. Because the adenosine agonists and antagonists employed were not selective at the receptor level, other possibilities are not excluded.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:37:50