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Titolo:
P53 MUTATIONS IN COLORECTAL CANCERS IN THE PATIENTS OF METROPOLITAN NEW-YORK
Autore:
VANDENBROEK MH; JHANWAR SC; FODDE R; CHAGANTI RSK; KHAN PM;
Indirizzi:
LEIDEN UNIV,SYLVIUS LAB,MGC DEPT HUMAN GENET,POB 9503 2300 RA LEIDEN NETHERLANDS MEM SLOAN KETTERING CANC CTR NEW YORK NY 00000
Titolo Testata:
Anticancer research
fascicolo: 5C, volume: 13, anno: 1993,
pagine: 1769 - 1772
SICI:
0250-7005(1993)13:5C<1769:PMICCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADIENT GEL-ELECTROPHORESIS; GENE; CARCINOMA; ALLELES; TUMORS; OCCUR; DNA;
Keywords:
P53 MUTATIONS; DENATURING GRADIENT GEL ELECTROPHORESIS; COLORECTAL CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Vandenbroek et al., "P53 MUTATIONS IN COLORECTAL CANCERS IN THE PATIENTS OF METROPOLITAN NEW-YORK", Anticancer research, 13(5C), 1993, pp. 1769-1772

Abstract

An unselected series of 19 colorectal adenocarcinomas obtained from patients treated by surgery at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, USA was investigated for mutations in exons 5, 6, 7 and 8 of the p53 gene. Ten of the tumors revealed at least one somaticmutation either in the exon 5 or 8. Two of them were found to carry two somatic mutations each. The DGGE pattern of one of these two tumorsindicated that it contained two different clonal cell populations; a similar assessment was not possible in the other tumor. Sequence analysis of all the observed variants showed that eighty percent of the mutations were due to transitions and that half of them were at mutational hot spot codons, 175 and 273.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:20:19