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Titolo:
BONE-MINERAL STATUS OF WOMEN WITH MARFAN-SYNDROME
Autore:
KOHLMEIER L; GASNER C; MARCUS R;
Indirizzi:
VET AFFAIRS MED CTR,GRECC 182B,3801 MIRAND AVE PALO ALTO CA 94304 VET AFFAIRS MED CTR,GRECC 182B,3801 MIRAND AVE PALO ALTO CA 94304 STANFORD UNIV,MED CTR,DIV ENDOCRINOL STANFORD CA 94305 STANFORD UNIV,MED CTR,MARFAN SYNDROME CLIN STANFORD CA 94305
Titolo Testata:
The American journal of medicine
fascicolo: 6, volume: 95, anno: 1993,
pagine: 568 - 572
SICI:
0002-9343(1993)95:6<568:BSOWWM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLIN; GENE; MANIFESTATIONS; CHROMOSOME-15; ABNORMALITIES; FRACTURES; MASS; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L. Kohlmeier et al., "BONE-MINERAL STATUS OF WOMEN WITH MARFAN-SYNDROME", The American journal of medicine, 95(6), 1993, pp. 568-572

Abstract

PURPOSE: With effective surgical correction of vascular abnormalities, skeletal health is an important issue for patients with Marfan syndrome. Osteopenia has been radiographically described, yet no systematicevaluation of bone status has been published. The purpose of this study was to determine the bone mineral density (BMD, g/cm2) in women with Marfan syndrome. PATIENTS AND METHODS: Seventeen women, 37.2 +/- 7.3years old, with Marfan syndrome were studied. Dual energy x-ray absorptiometry (DXA) was used to measure BMD at the lumbar spine (L2-L4), proximal femur, and total body in all subjects. Scoliosis scores were assigned from 0 (no curvature) to 3 (severe curvature). RESULTS. HighlySignificant deficits in BMD were observed at the proximal femur (p = 0.0001) as well as of the whole body (p <0.05). Femoral neck BMD Z-score (mean +/- SD) = -1.36 +/- 0.94, trochanter Z = -1.07 +/- 0.80, and intertrochanter Z = -1.44 +/- 0.71; whole-body BMD Z-score = -0.30 +/-0.16. BMD at L2-L4, however, did not differ from age-predicted values, Z = -0.48 +/- 1.16. There was no significant association between BMDand scoliosis, nor between BMD and fracture history. To correct for bone size, the bone mineral apparent density (BMAD, g/cm3) was calculated. The femoral neck BMAD values (mean +/- SD) were significantly lower than predicted (0.125 +/- 0.02 versus 0.147 +/- 0.001 g/cm3, p <0.001). All subjects had normal menarche, and 15 reported regular menses. There was no history of nontraumatic fracture. CONCLUSIONS: Women withMarfan syndrome have bone deficits at the proximal femur as well as of the whole body. This deficit is not related to scoliosis and persists when corrected for bone size. Women with Marfan syndrome may be at increased risk for proximal femoral fracture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:47:00