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Titolo:
IDENTIFICATION OF A 7 TRANSMEMBRANE HELIX RECEPTOR FOR CORTICOTROPIN-RELEASING FACTOR AND SAUVAGINE IN MAMMALIAN BRAIN
Autore:
CHANG CP; PEARSE RV; OCONNELL S; ROSENFELD MG;
Indirizzi:
UNIV CALIF SAN DIEGO,SCH MED,HOWARD HUGHES MED INST,DEPT MED,EUKARYOTREGULATORY BIOL PROGRAM LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,GRAD PROGRAM BIOMED LA JOLLA CA 92093
Titolo Testata:
Neuron
fascicolo: 6, volume: 11, anno: 1993,
pagine: 1187 - 1195
SICI:
0896-6273(1993)11:6<1187:IOA7TH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLATE-CYCLASE ACTIVITY; ANTERIOR-PITUITARY CELLS; FACTOR CRF RECEPTORS; CALCITONIN GENE; FACTOR-BINDING; MESSENGER-RNA; UROTENSIN-I; CYCLIC-AMP; G-PROTEIN; AUTORADIOGRAPHIC LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Chang et al., "IDENTIFICATION OF A 7 TRANSMEMBRANE HELIX RECEPTOR FOR CORTICOTROPIN-RELEASING FACTOR AND SAUVAGINE IN MAMMALIAN BRAIN", Neuron, 11(6), 1993, pp. 1187-1195

Abstract

We have identified and characterized cDNAs encoding a novel receptor that is a member of a distinct class of seven transmembrane helix, G(s)-coupled receptors. This receptor mediates ligand-dependent stimulation of intracellular cAMP levels in response to physiologic concentrations of corticotropin-releasing factor (CRF) and to the related frog skin peptide, sauvagine. The pattern of CRF receptor mRNA expression in the brain, pituitary gland, and other organs corresponds precisely to that predicted for the classic CRF receptor, suggesting that this receptor serves to mediate the known biological effects of CRF on behavior, stress, and homeostasis. Alternative splicing events generate a second, relatively abundant gene product expressed in a distinct ontogenicpattern. These findings serve to identify the receptor for an important neuropeptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:03:19