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Titolo:
THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER
Autore:
VANOOSTERHOUT AGM; THUNNISSEN FBJM; VOLOVICS A; VANDENPOL M; TENVELDE GPM; TWIJNSTRA A;
Indirizzi:
UNIV LIMBURG HOSP,DEPT NEUROL,POB 5800 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT NEUROL,POB 5800 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT PULMONOL 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT PATHOL 6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT MED STAT 6202 AZ MAASTRICHT NETHERLANDS
Titolo Testata:
International journal of oncology
fascicolo: 1, volume: 4, anno: 1994,
pagine: 201 - 205
SICI:
1019-6439(1994)4:1<201:TROHSI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM METASTASES; PROGNOSTIC-SIGNIFICANCE; CARCINOMA; CLASSIFICATION; SUBCLASSIFICATION; HETEROGENEITY; EXPERIENCE; PROGRESS; LINES;
Keywords:
SMALL CELL LUNG CANCER; HISTOLOGIC SUBTYPING; SUBCLASSIFICATION OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER; CENTRAL NERVOUS SYSTEM METASTASES; BRAIN METASTASES; PARANEOPLASTIC SYNDROMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.G.M. Vanoosterhout et al., "THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER", International journal of oncology, 4(1), 1994, pp. 201-205

Abstract

We examined the significance of histologic subtyping of small cell lung cancer (SCLC) as a prognostic factor for neurologic complications and in particular central nervous system (CNS) metastases. Pretreatmentmaterial of 239 consecutive patients with SCLC was retrospectively reexamined according to the histologic subclassification of the Pathology Panel of the International Association for the Study of Lung Cancer. Besides the classic small cell type (n=178), this subclassification distinguishes two variant cell types: mixed (n=31) and combined (n=1), which were treated as one group in the further statistical analysis. Twenty nine cases were not classified, for the following reasons: autopsy material only (n=14), slides missing (n=7), and initial SCLC diagnosis changed (n=8). The results showed that neurologic complications registered in a prospective neurologic follow-up were common in both subtypes and predominantly metastatic in nature. The data did not reveal any significant difference between histologic subtypes with regard to CNS metastases and brain metastatic-free survival. Paraneoplastic syndromes tended to occur more frequently in patients with classic small cell type. However, this relationship needs further study. It was concluded that no prognostic relevance exists for histologic subtyping withrespect to neurologic complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:13:09