Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STIMULATION OF ENDOTHELIN MESSENGER-RNA AND SECRETION IN HUMAN ENDOTHELIAL-CELLS BY FK-506
Autore:
TAKEDA Y; YONEDA T; ITO Y; MIYAMORI I; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 22, anno: 1993, supplemento:, 8
pagine: 190000310 - 190000312
SICI:
0160-2446(1993)22:<190000310:SOEMAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; MESENTERIC-ARTERIES; TRANSPLANTATION; FK506; RATS;
Keywords:
ENDOTHELIN; MESSENGER RNA; FK 506; CYCLOSPORINE; ENDOTHELIAL CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "STIMULATION OF ENDOTHELIN MESSENGER-RNA AND SECRETION IN HUMAN ENDOTHELIAL-CELLS BY FK-506", Journal of cardiovascular pharmacology, 22, 1993, pp. 190000310-190000312

Abstract

FK 506 is a powerful new immunosuppressant that is more effective in preventing and treating allograft rejection than cyclosporine (CyA). This study was undertaken to examine the effect of FK 506 on stimulation of endothelin-1 (ET-1) mRNA and secretion of ET-1 in human endothelial cells (EC) compared with the effects of CyA. The dose of 0.1 muM ofCyA used in clinical practice induced expression of ET-1 mRNA and increased secretion of ET-1 in EC. The same dose of FK 506 had the same effect. A clinical dose of 0.01 muM of FK 506 did not induce expressionof ET-1 mRNA and did not increase the secretion of ET-1 in EC. These findings suggest that the lower incidence of complications seen with FK 506 is due in part to its use at a lower clinical dose compared withthat of CyA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:31:48