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Titolo:
2 SUBTYPES OF THE ENDOTHELIN RECEPTOR (ET(A) AND ET(B)) MEDIATE VASOCONSTRICTION IN THE PERFUSED RAT-HEART
Autore:
BALWIERCZAK JL;
Indirizzi:
CIBA GEIGY CORP,RES DEPT,DIV PHARMACEUT SUMMIT NJ 07901
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 22, anno: 1993, supplemento:, 8
pagine: 190000248 - 190000251
SICI:
0160-2446(1993)22:<190000248:2SOTER>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENT; ETA;
Keywords:
ENDOTHELIN; RECEPTOR SUBTYPE; IRL 1620; RAT CORONARY RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Balwierczak, "2 SUBTYPES OF THE ENDOTHELIN RECEPTOR (ET(A) AND ET(B)) MEDIATE VASOCONSTRICTION IN THE PERFUSED RAT-HEART", Journal of cardiovascular pharmacology, 22, 1993, pp. 190000248-190000251

Abstract

The effects of endothelin-1 (ET-1) are mediated by two subclasses of the endothelin receptor, ET(A) and ET(B). The Langendorff perfused ratheart was used to determine the endothelin receptor subtype mediatingrat coronary vasoconstriction. ET-1 (EC50 = 1.5 x 10(-10) M) and endothelin-3 (ET-3)(10(-11)-3 x 10(-8) M) caused dose-dependent increases in coronary perfusion pressure. BQ123, a selective antagonist of the ET(A)-receptor subtype, did not cause a parallel shift in the dose-response curves of ET-1 or ET-3. In the presence of 1-3 x 10(-6) M BQ-123,ET-1 and ET-3 exhibited biphasic dose-response curves, suggesting that vasoconstriction was caused by two receptors. The ET(B)-selective agonist Suc-[Glu9,Ala11,15]-ET-1(8-21) (IRL 1620) maximally increased perfusion pressure by approximately 50% of the maximal response to ET-1 and was not inhibited by BQ-123. These data suggest that the rat coronary vasoconstrictor effects of ET-1 and ET-3 are mediated by both ET(A) and ET(B) receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:26:37