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Titolo:
VASOCONSTRICTION IN THE RAT-KIDNEY INDUCED BY ENDOTHELIN-1 IS BLOCKEDBY PD-145065
Autore:
WELLINGS RP; WARNER TD; THIEMERMANN C; CRISTOL JP; CORDER R; VANE JR;
Indirizzi:
ST BARTHOLOMEWS HOSP,SCH MED,WILLIAM HARVEY RES INST,CHARTERHOUSE SQ LONDON EC1M 6BQ ENGLAND ST BARTHOLOMEWS HOSP,SCH MED,WILLIAM HARVEY RES INST,CHARTERHOUSE SQ LONDON EC1M 6BQ ENGLAND
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 22, anno: 1993, supplemento:, 8
pagine: 190000103 - 190000106
SICI:
0160-2446(1993)22:<190000103:VITRIB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE RENAL-FAILURE; RECEPTOR; CLONING; SUBTYPE; POTENT;
Keywords:
PD-145065; BQ-123; FR-139317; RENAL VASOCONSTRICTOR EFFECTS; ENDOTHELIN RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Wellings et al., "VASOCONSTRICTION IN THE RAT-KIDNEY INDUCED BY ENDOTHELIN-1 IS BLOCKEDBY PD-145065", Journal of cardiovascular pharmacology, 22, 1993, pp. 190000103-190000106

Abstract

We have previously shown that the receptors mediating the renal and systemic vasoconstrictor effects of endothelin-I (ET-1) are of two distinct endothelin receptor subtypes. Here, we evaluate the effect of PD 145065, a nonselective endothelin receptor antagonist, on the renal vasoconstrictor effects of ET-1 in the rat kidney. ET-1 induced concentration-dependent increases in perfusion pressure in the isolated perfused kidney of the rat. The ET(A) receptor-selective antagonists BQ-123 (10 muM) and FR 139317 (10 muM) lowered the ET-1-induced rise in perfusion pressure by 57% and 61%, respectively, at 3 x 10(-10) M ET-1. By comparison, the ET-1-induced vasoconstriction was fully antagonized (96% inhibition) by PD 145065 (10 muM). In the anesthetized rat, ET-1 produced a dose-dependent increase in mean arterial pressure, which was attenuated by PD 145065. The initial depressor response to ET-1 was completely blocked by PD 145065, as were the reduction in renal blood flow and increase in renal vascular resistance induced by ET-1. These results suggest that both the ET(A) and a non-ET(A) receptor subtype play an important role in mediating the vasoconstrictor effects of ET-1 in the rat kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:16:21