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Titolo:
REDUCED MICROBICIDAL AND ANTITUMOR ACTIVITIES, OF HUMAN MONOCYTES AFTER INGESTION OF PLASMODIUM-FALCIPARUM-INFECTED RED-BLOOD-CELLS
Autore:
FIORI PL; RAPPELLI P; MIRKARIMI SN; GINSBURG H; CAPPUCCINELLI P; TURRINI F;
Indirizzi:
HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL UNIV SASSARI,INST MICROBIOL & VIROL SASSARI ITALY UNIV TURIN,DEPT GENET BIOL & MED CHEM I-10124 TURIN ITALY
Titolo Testata:
Parasite immunology
fascicolo: 12, volume: 15, anno: 1993,
pagine: 647 - 655
SICI:
0141-9838(1993)15:12<647:RMAAAO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE ACTIVATION; NECROSIS FACTOR; MURINE MALARIA; PHAGOCYTOSIS; IMMUNE; IMMUNOSUPPRESSION; ERYTHROCYTES; INVOLVEMENT; DEPENDENCE; CAPACITY;
Keywords:
PLASMODIUM FALCIPARUM; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; CANDIDA ALBICANS; MONOCYTE; PHAGOCYTOSIS; CANCER CELLS; MALARIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Fiori et al., "REDUCED MICROBICIDAL AND ANTITUMOR ACTIVITIES, OF HUMAN MONOCYTES AFTER INGESTION OF PLASMODIUM-FALCIPARUM-INFECTED RED-BLOOD-CELLS", Parasite immunology, 15(12), 1993, pp. 647-655

Abstract

Oxidatively stressed red blood cells (RBC) and Plasmodium falciparum-infected RBC (PRBC) are avidly phagocytosed by human peripheral monocytes. Following the ingestion of PRBC the monocytes' ability to phagocytose PRBC and to generate aggressive oxidative compounds is severely impaired. In the present work the microbicidal and anti-tumour capacities of monocytes fed with diamide-treated RBC and PRBC harbouring mature (trophozoite) parasites have been investigated. The capacity, of thelatter, but not of the former, to phagocytose Escherichia coli and Staphylococcus aureus and to kill them, as well as ingested Candida albicans cells intracellularly, was found to be markedly impaired. Monocytes that have ingested PRBC had a significantly reduced cytostatic and cytolytic activities against a lymphoblastic tumour cell line. Monocytes fed with oxidatively stressed RBC had normal or sometimes even greater anti-tumour activities. Monocytes that have ingested PRBC showed areduced capability to produce superoxide following stimulation with phorbol ester. Such impairment in monocyte functions may explain the reduced antibacterial and anti-tumour activities of monocytes in malariapatients, and could be consequential to their ability to resist bacterial infections and to provide means for the control of tumour development in those patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:54:26