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Titolo:
PROLIFERATIVE INDEX OF HUMAN LUTEINIZED GRANULOSA-CELLS VARIES AS A FUNCTION OF OVARIAN RESERVE
Autore:
SEIFER DB; CHARLAND C; BERLINSKY D; PENZIAS AS; HANING RV; NAFTOLIN F; BARKER BE;
Indirizzi:
BROWN UNIV,WOMEN & INFANTS HOSP,SCH MED,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL PROVIDENCE RI 02905 BROWN UNIV,RHODE ISL HOSP,SCH MED,DEPT PATHOL PROVIDENCE RI 02903 TUFTS UNIV,SCH MED,DIV REPROD ENDOCRINOL BOSTON MA 02111 YALE UNIV,SCH MED,DEPT OBSTET & GYNECOL NEW HAVEN CT 06510
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 6, volume: 169, anno: 1993,
pagine: 1531 - 1535
SICI:
0002-9378(1993)169:6<1531:PIOHLG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING-HORMONE LEVEL; INVITRO FERTILIZATION; OVULATION INDUCTION; CHRONOLOGICAL AGE; WOMEN; FERTILITY; PREGNANCY; DECLINE;
Keywords:
GRANULOSA CELL; OVARIAN RESERVE; PROLIFERATIVE INDEX; FLOW CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Seifer et al., "PROLIFERATIVE INDEX OF HUMAN LUTEINIZED GRANULOSA-CELLS VARIES AS A FUNCTION OF OVARIAN RESERVE", American journal of obstetrics and gynecology, 169(6), 1993, pp. 1531-1535

Abstract

OBJECTIVE: We examined whether the proliferative index of luteinized granulosa cells, as determined by flow cytometry, varied as a functionof a woman's ovarian reserve, as reflected by follicular-phase day 3 serum follicle-stimulating hormone. STUDY DESIGN: This prospective cohort study consisted of 19 women of similar chronologic age preparing for in vitro fertilization-embryo who met specific day 3 serum follicle-stimulating hormone criteria. The ''low follicle-stimulating hormone'' group consisted of 11 women with day 3 serum follicle-stimulating hormone levels less-than-or-equal-to 6 IU/L. The ''high follicle-stimulating hormone'' group consisted of eight women with day 3 serum follicle-stimulating hormone levels greater-than-or-equal-to 18 IU/L. A totalof 56 preovulatory follicles containing greater-than-or-equal-to 10(4) luteinized granulosa cells were examined by flow cytometry. The low follicle-stimulating hormone group was compared with the high follicle-stimulating hormone group to examine proliferative index as a function of serum day 3 follicle-stimulating hormone levels. RESULTS: The lowfollicle-stimulating hormone group had a greater proliferative index (11.1 % +/- 0.4%) than did the high follicle-stimulating hormone group(8.3% +/- 0.6%), p < 0.001). This study demonstrates that in spite ofthe same chronologic age, luteinized granulosa cells from preovulatory follicles of women with day 3 serum follicle-stimulating hormone levels greater-than-or-equal-to 18 IU/L have a 25% decreased proliferative index compared with luteinized granulosa cells from women with day 3serum follicle-stimulating hormone levels less-than-or-equal-to 6. CONCLUSIONS: This suggests that granulosa cell proliferation is influenced by ovarian reserve and may explain in part the more favorable response to ovulation induction protocols that younger women demonstrate compared with women of more advanced reproductive age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:32:26