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Titolo:
EVALUATION OF ISCHEMIA-REPERFUSION INJURY BY MALONDIALDEHYDE, GLUTATHIONE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE - LACK OF SPECIFIC LOCAL-EFFECTS IN DIVERSE PARTS OF THE DOG HEART FOLLOWING ACUTE CORONARY-OCCLUSION
Autore:
ONDREJICKOVA O; ZIEGELHOEFFER A; GABAUER I; SOTNIKOVA R; STYK J; GIBALA P; SEDLAK J; HORAKOVA L;
Indirizzi:
SLOVAK ACAD SCI,INST HEART RES,DUBRAVSKA CESTA 9 84233 BRATISLAVA SLOVAKIA SLOVAK ACAD SCI,INST HEART RES 84233 BRATISLAVA SLOVAKIA SLOVAK ACAD SCI,INST EXPTL PHARMACOL BRATISLAVA SLOVAKIA
Titolo Testata:
Cardioscience
fascicolo: 4, volume: 4, anno: 1993,
pagine: 225 - 230
SICI:
1015-5007(1993)4:4<225:EOIIBM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTISCHEMIC REPERFUSION; MYOCARDIAL-FUNCTION; FREE-RADICALS; METABOLISM; RAT; ARRHYTHMIAS; PROTECTION; AFFINITY; CALCIUM; OXYGEN;
Keywords:
ISCHEMIA-REPERFUSION; GAMMA-GLUTAMYL TRANSPEPTIDASE; MALONDIALDEHYDE; GLUTATHIONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
O. Ondrejickova et al., "EVALUATION OF ISCHEMIA-REPERFUSION INJURY BY MALONDIALDEHYDE, GLUTATHIONE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE - LACK OF SPECIFIC LOCAL-EFFECTS IN DIVERSE PARTS OF THE DOG HEART FOLLOWING ACUTE CORONARY-OCCLUSION", Cardioscience, 4(4), 1993, pp. 225-230

Abstract

Alterations in the levels of glutathione, glutathione disulfide, malondialdehyde, and the activity of gamma-glutamyl transpeptidase in nonischemic and ischemic parts of the left ventricle and in the right ventricle were studied in canine hearts after occlusion of the left anterior descending coronary artery for 60 minutes and subsequent reperfusion for 20 minutes. Ischemia caused no significant change in malondialdehyde concentration and gamma-glutamyl transpeptidase activity in ischemic or nonischemic parts of the left ventricle, but it increased the activity of gamma-glutamyl transpeptidase in the continuously perfused right ventricle. Reperfusion of the ischemic areas of the left ventricle was accompanied by accumulation of malondialdehyde and an increase in gamma-glutamyl transpeptidase activity, not only in the reperfused and adjacent areas of the left ventricle, but also in the continuouslyperfused right ventricle. An increase in the level of glutathione disulfide and decrease in glutathione occurred in all parts of the myocardium during coronary occlusion; these changes were maintained in reperfusion. The findings indicate that the effects of acute occlusion and reperfusion of the left anterior descending coronary artery on myocardial concentrations of glutathione, glutathione disulfide and malondialdehyde or gamma-glutamyl transpeptidase activity are not confined to the local area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/08/20 alle ore 09:53:32