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Titolo:
THE USE OF GASTRIC ACID-INHIBITORY DRUGS - PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONSIDERATIONS
Autore:
WALDUM HL; BRENNA E; KLEVELAND PM; SANDVIK AK; SYVERSEN U;
Indirizzi:
UNIV HOSP TRONDHEIM,DEPT MED N-7006 TRONDHEIM NORWAY
Titolo Testata:
Alimentary pharmacology & therapeutics
fascicolo: 6, volume: 7, anno: 1993,
pagine: 589 - 596
SICI:
0269-2813(1993)7:6<589:TUOGAD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL-ULCER PATIENTS; PERFUSED RAT STOMACH; 24-HOUR INTRAGASTRIC ACIDITY; ENTEROCHROMAFFIN LIKE CELLS; REFLUX ESOPHAGITIS; HELICOBACTER-PYLORI; PLASMA-GASTRIN; PERNICIOUS-ANEMIA; ENDOCRINE-CELLS; PEPTIC-ULCER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
H.L. Waldum et al., "THE USE OF GASTRIC ACID-INHIBITORY DRUGS - PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONSIDERATIONS", Alimentary pharmacology & therapeutics, 7(6), 1993, pp. 589-596

Abstract

All vertebrates secrete gastric acid. Acid denatures the proteins in the food and thus makes them more accessible to proteolytic enzymes, and it kills swallowed micro-organisms. Gastric acid plays an importantpathogenetic role in peptic ulcer disease and reflux oesophagitis. Inthese diseases, drugs that inhibit secretion of gastric acid will heal the lesions and suppress the symptoms. However, both reflux oesophagitis and peptic ulcer tend to recur when the acid-inhibitory treatmentis stopped. Therefore, these patients often require long-term treatment with acid-inhibitors. In this overview the potential risks of long-term profound inhibition of acid secretion, raising the pH above 4 fora considerable time, resulting in reduced killing of micro-organisms and secondary hypergastrinaemia, are discussed. Gastrin regulates boththe function (production and release of histamine) and growth of the enterochromaffin-like (ECL) cell. Hitherto, the role that this cell plays in gastric carcinogenesis appears to have been underestimated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:08:15