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Titolo:
ALZHEIMERS-DISEASE - A PISCATORIAL TREK
Autore:
VANEERDEWEGH P; HAMPE CL; SUAREZ BK; REICH T;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
Genetic epidemiology
fascicolo: 6, volume: 10, anno: 1993,
pagine: 395 - 400
SICI:
0741-0395(1993)10:6<395:A-APT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE;
Keywords:
AFFECTED-PEDIGREE-MEMBER METHOD; MARKER ALLELE FREQUENCY; KINSHIP COEFFICIENT; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
P. Vaneerdewegh et al., "ALZHEIMERS-DISEASE - A PISCATORIAL TREK", Genetic epidemiology, 10(6), 1993, pp. 395-400

Abstract

The evidence for linkage between Alzheimer's disease and markers on both chromosomes 19 and 21 [Pericak-Vance et al., 1991] by the affected-pedigree-member (APM) method [Weeks and Lange, 19881 cannot be replicated on any of the available GAW8 data sets when marker allele frequencies are estimated from the combined sample. The strong dependence of the APM method on accurate estimation of marker allele frequencies, and the effects of noninformative pairs and of genetic distance in informative pairs of relatives are illustrated. (C) 1993 Wiley-Liss, Inc.

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Documento generato il 29/09/20 alle ore 16:37:11