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Titolo:
INFLUENCE OF HYPO-OSMOLALITY ON THE ACTIVITY OF SHORT-CHAIN NEUTRAL AMINO-ACID CARRIERS IN TROUT (SALMO-TRUTTA) RED-BLOOD-CELLS
Autore:
GALLARDO MA; ALBI JL; SANCHEZ J;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT FISIOL,AVDA DIAGONAL 645 E-08028 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT FISIOL E-08028 BARCELONA SPAIN
Titolo Testata:
The Journal of membrane biology
fascicolo: 2, volume: 155, anno: 1997,
pagine: 113 - 119
SICI:
0022-2631(1997)155:2<113:IOHOTA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-ALANINE UPTAKE; TAURINE TRANSPORT; SKATE ERYTHROCYTES; GLYCINE TRANSPORT; FISH ERYTHROCYTES; VOLUME REGULATION; ANION CHANNELS; RAJA-ERINACEA; HEPATOCYTES; EFFLUX;
Keywords:
GLYCINE UPTAKE; HYPO-OSMOLALITY; RED BLOOD CELLS; ASC SYSTEM; GLY SYSTEM; ASC SYSTEM; L SYSTEM; VOLUME-SENSITIVE CHANNEL; TROUT (SALMO TRUTTA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Gallardo et al., "INFLUENCE OF HYPO-OSMOLALITY ON THE ACTIVITY OF SHORT-CHAIN NEUTRAL AMINO-ACID CARRIERS IN TROUT (SALMO-TRUTTA) RED-BLOOD-CELLS", The Journal of membrane biology, 155(2), 1997, pp. 113-119

Abstract

The present study shows that in trout red blood cells the activity ofsome amino acid carriers, not directly involved in cell volume regulation, is affected by external osmolality. Glycine uptake has been usedas the experimental approach because it was shown previously that it is effected by different carriers, namely the Na+ dependent ASC and Gly systems, as well as the Na+- independent asc and L systems. An increase in the uptake through the Gly system and the two Na+-independent carriers was found, while the ASC system appeared to be downregulated. Those systems whose activities were increased by hypoosmolality did not share the mechanism by which this increase was obtained. Thus, the Gly system was sensitive to intracellular ionic changes, while the Na+-independent systems were mechanically stimulated, as assessed by the iso-osmotic swelling caused by ammonium chloride. On the other hand, avolume-sensitive transporter may be present in trout red blood cells,which is involved in the swelling-induced glycine movement, as can bededuced from the effect of some inhibitors such as pyridoxal phosphate, DIDS (4,4'-diisothiocyanate-stilbene-2,2'-disulfonic acid) and quinine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:44:20