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Titolo:
EFFECTS OF LUMINAL STIMULI ON POLYAMINE METABOLISM IN THE SMALL-INTESTINE OF THE RAT - THE ROLE OF ENTERIC NERVES
Autore:
JANSSON M; NILSSON BO; ROSENGREN E; EKSTROM J; LUNDGREN O;
Indirizzi:
UNIV GOTEBORG,DEPT PHYSIOL,MED AREGATAN 11 S-41390 GOTHENBURG SWEDEN UNIV GOTEBORG,DEPT PHYSIOL S-41390 GOTHENBURG SWEDEN UNIV GOTEBORG,DEPT PHARMACOL S-41390 GOTHENBURG SWEDEN LUND UNIV,DEPT PHYSIOL LUND SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 4, volume: 149, anno: 1993,
pagine: 483 - 490
SICI:
0001-6772(1993)149:4<483:EOLSOP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSEPITHELIAL POTENTIAL DIFFERENCE; SALIVARY-GLANDS; ALKALINE SECRETION; INTRAMURAL NERVES; INVIVO; DFMO;
Keywords:
ATROPINE; CHOLERA TOXIN; ENTERIC NERVOUS SYSTEM; HEAT STABLE ENTEROTOXIN OF ESCHERICHIA COLI (STA); HEXAMETHONIUM; LIDOCAINE; ORNITHINE DECARBOXYLASE (ODC); POLYAMINES; SMALL INTESTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Jansson et al., "EFFECTS OF LUMINAL STIMULI ON POLYAMINE METABOLISM IN THE SMALL-INTESTINE OF THE RAT - THE ROLE OF ENTERIC NERVES", Acta Physiologica Scandinavica, 149(4), 1993, pp. 483-490

Abstract

The aim of this study was to investigate to what extent polyamine metabolism in the small intestine of the rat is controlled by the entericnervous system. Polyamine metabolism was followed by measuring the activity of ornithine decarboxylase (ODC) and in some instances also thecontent of polyamines (putrescine, spermidine and spermine). ODC activity in the intestine was increased when intraluminal pressure was increased and 3 h after placing cholera toxin in the intestinal lumen. Cholera toxin also increased the tissue putrescine content. Atropine or hexamethonium given i.v. did not influence the evoked changes of ODC activity. The pressure induced changes were not decreased by placing lidocaine on the serosal surface. On the other hand, the ODC activity ofcontrol segments were decreased by hexamethonium or atropine. The presence of glucose in the intestinal perfusate did not augment tissue ODC activity, neither did the heat stable enterotoxin from Escherichia coli (STa). It is concluded that the effect on polyamine metabolism evoked by luminal pressure or cholera toxin seems not to be mediated via nerves, while nerves seem to influence ODC activity during control conditions. The experiments with enterotoxins suggest that cAMP is the intracellular second messenger controlling intestinal ODC activity.

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Documento generato il 05/07/20 alle ore 00:18:48