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Titolo:
RELEASE OF DOPAMINE IN THE NUCLEUS-ACCUMBENS CAUSED BY STIMULATION OFTHE SUBICULUM IN FREELY MOVING RATS
Autore:
BRUDZYNSKI SM; GIBSON CJ;
Indirizzi:
UNIV WESTERN ONTARIO HOSP,DEPT CLIN NEUROL SCI,POB 5339,POSTAL STN A LONDON ON N6A 5A5 CANADA UNIV WESTERN ONTARIO HOSP,DEPT PATHOL LONDON ON N6A 5A5 CANADA
Titolo Testata:
Brain research bulletin
fascicolo: 4, volume: 42, anno: 1997,
pagine: 303 - 308
SICI:
0361-9230(1997)42:4<303:RODITN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; IDENTIFIED NEURONS; LOCOMOTOR-ACTIVITY; SYNAPTIC CLEFT; HIPPOCAMPAL; PROJECTIONS; TERMINALS; GLUTAMATE; INPUTS; TRANSMISSION;
Keywords:
VENTRAL SUBICULUM; MESOLIMBIC DOPAMINERGIC SYSTEM; DOPAMINE; GLUTAMATE; NMDA; LOCOMOTOR ACTIVITY; IN VIVO MICRODIALYSIS; DOPAC; HVA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Brudzynski e C.J. Gibson, "RELEASE OF DOPAMINE IN THE NUCLEUS-ACCUMBENS CAUSED BY STIMULATION OFTHE SUBICULUM IN FREELY MOVING RATS", Brain research bulletin, 42(4), 1997, pp. 303-308

Abstract

Stimulation of the ventral subiculum of the hippocampus activates thehippocampal-accumbens pathway and increases locomotor activity. Dopaminergic terminals in the nucleus accumbens have also been implicated in initiation of locomotor activity, and the release of dopamine in thenucleus accumbens is critical far locomotor responses initiated from the subiculum to occur. We have demonstrated release of dopamine in the nucleus accumbens using in vivo microdialysis after stimulation of the ventral subiculum with NMDA. Extracellular dopamine lever in the nucleus accumbens was significantly increased by 40% over baseline as a result of NMDA stimulation of the ventral subiculum. This stimulation also caused more than a 40-fold increase in horizontal activity and total distance covered by the rats. Injection of saline into the subiculum caused neither a change in the dopamine revel nor an increase in animal's activity. The dynamics of the measured changes in dopamine overflow correlated with the time course of locomotor changes. The resultsdemonstrate that stimulation of the ventral subiculum causes release of dopamine in the nucleus accumbens which parallels the increase in locomotor activity. Copyright (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:16:07