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Titolo:
POLYCYTHEMIA-VERA AND CEREBRAL BLOOD-FLOW - A PRELIMINARY-STUDY WITH TRANSCRANIAL DOPPLER
Autore:
FIERMONTE G; SPIRITI MAA; LATAGLIATA R; PETTI MC; GIACOMINI P;
Indirizzi:
UNIV ROMA LA SAPIENZA,IST CLIN MALATTIE NERVOSE & MENTALI,VIALE UNIV 30 I-00185 ROME ITALY UNIV ROMA LA SAPIENZA,DEPT HUMAN BIOPATHOL,DIV HAEMATOL ROME ITALY
Titolo Testata:
Journal of internal medicine
fascicolo: 6, volume: 234, anno: 1993,
pagine: 599 - 602
SICI:
0954-6820(1993)234:6<599:PACB-A>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYTHEMIA-VERA; HEMATOCRIT; ULTRASOUND; VELOCITY; VALUES;
Keywords:
CEREBRAL BLOOD FLOW; HEMATOCRIT; HEMOGLOBIN,; POLYCYTHEMIA VERA; TRANSCRANIAL DOPPLER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G. Fiermonte et al., "POLYCYTHEMIA-VERA AND CEREBRAL BLOOD-FLOW - A PRELIMINARY-STUDY WITH TRANSCRANIAL DOPPLER", Journal of internal medicine, 234(6), 1993, pp. 599-602

Abstract

Objectives. The purpose of this study has been to investigate by ultrasonographic methods the now velocities of cerebral arteries because increased blood viscosity due to haematocrit elevation can cause neurological symptoms in polycythaemia vera patients, because of the resulting decrease in cerebral now. Subjects and design. Twenty newly diagnosed patients, with haemoglobin values of > 18 g dl(-1) and/or an haematocrit of > 50%, were examined by transcranial Doppler. Recordings wereperformed in basal conditions and after pharmacological and/or phlebotomic treatment, when haematocrit values were less than or equal to 50%. Blood velocities were evaluated in middle (MCA), anterior (ACA), posterior (PCA) cerebral arteries and in the basilar (BA) artery. Results. Basal recordings showed decreased velocities (MCA: 39.40+/-9.34cm s(-1); ACA: 34.05+/-10.25 cm s(-1); PCA: 31.46+/-5.97 cm s(-1); and BA:27.47+/- 7.42 cm s(-1)); pre- and post-treatment value differences observed in MCA, ACA and BA were highly significant (P < 0.001). Conclusions. A decrease in cerebral now could be a risk for multifocal micro-ischaemic cerebral infarctions leading, after several years, to a multiinfarct dementia; an early reduction in erythrocyte burden should be very useful in polycythaemic patients in preventing lacunar lesions.

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Documento generato il 13/07/20 alle ore 17:33:58