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Titolo:
CLINICAL-EVALUATION OF TL-201 SPECT IN SUPRATENTORIAL GLIOMAS - RELATIONSHIP TO HISTOLOGIC GRADE, PROGNOSIS AND PROLIFERATIVE ACTIVITIES
Autore:
ORIUCHI N; TAMURA M; SHIBAZAKI T; OHYE C; WATANABE N; TATENO M; TOMIYOSHI K; HIRANO T; INOUE T; ENDO K;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT NUCL MED MAEBASHI GUNMA 371 JAPAN GUNMA UNIV,SCH MED,DEPT NEUROSURG MAEBASHI GUNMA 371 JAPAN
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 12, volume: 34, anno: 1993,
pagine: 2085 - 2089
SICI:
0161-5505(1993)34:12<2085:COTSIS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; MONOCLONAL-ANTIBODY; GLUCOSE-UTILIZATION; TL-201 SPECT; BRAIN-TUMORS; BROMODEOXYURIDINE; DIAGNOSIS; RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
N. Oriuchi et al., "CLINICAL-EVALUATION OF TL-201 SPECT IN SUPRATENTORIAL GLIOMAS - RELATIONSHIP TO HISTOLOGIC GRADE, PROGNOSIS AND PROLIFERATIVE ACTIVITIES", The Journal of nuclear medicine, 34(12), 1993, pp. 2085-2089

Abstract

We performed (TI)-T-201 SPECT and cell kinetic studies on 28 presurgical patients with supratentorial gliomas by administering bromodeoxyuridine (BUdR). All patients had surgery and had follow-up for more than25 mo. In patients with grade IV glioma (198.1% +/- 32.8%, n = 10), the (TI)-T-201 index, expressed as the count rate of the tumor site to the count rate over the contralateral normal region, was significantlyhigher than that in patients with grade III glioma (140.5% +/- 15.1%,n = 4, p < 0.01) or low-grade glioma (104.1% +/- 22.6%, n = 14, p < 0.001). A significant correlation was observed between the (TI)-T-201 index and BUdR-positive cells in excised tumor specimens (r = 0.67, p <0.001). The (TI)-T-201 index of the 12 patients who died was higher than those who survived (173.2% Versus 122.4%, p < 0.01). These resultsshow the clinical utility of (TI)-T-201 brain SPECT in imaging supratentorial glioma and that the (TI)-T-201 index is representative of proliferative activity of the tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:29:39